Inhibition of influenza virus activity by the bovine seminal plasma protein PDC-109.

Inhibition of influenza virus activity by the bovine seminal plasma protein PDC-109.
Eur Biophys J. 2019 Jun 20;:
Authors: Welke RW, Haralampiev I, Schröter F, Braun BC, Herrmann A, Sieben C, Müller P
Abstract
A number of viruses causing sexually transmissible diseases are transmitted via mammalian seminal plasma. Several components of seminal plasma have been shown to influence those viruses and their physiological impact. To unravel whether components of seminal plasma could affect viruses transmitted via other pathways, it was investigated here whether the bovine seminal plasma protein PDC-109, belonging to the Fn-type 2 protein family, influences the activity of influenza A viruses, used as a model for enveloped viruses. We found that PDC-109 inhibits the fusion of influenza virus with human erythrocyte membranes and leads to a decreased viral infection in MDCK cells. In the presence of the head group of the phospholipid phosphatidylcholine, phosphorylcholine, the inhibitory effect of PDC-109 was attenuated. This indicates that the impact of the protein is mainly caused by its binding to viral and to erythrocyte membranes thereby interfering with virus-cell binding. Our study underlines that Fn-type 2 proteins have to be considered as new antiviral components present in mammalian seminal plasma.
PMID: 31222413 [PubMed - as supplied by publisher]

Source: European Biophysics Journal : EBJ - June 19, 2019 Category: Physics Authors: Welke RW, Haralampiev I, Schröter F, Braun BC, Herrmann A, Sieben C, Müller P Tags: Eur Biophys J Source Type: research