Exposure to air pollution during pregnancy and newborn liver function.

Exposure to air pollution during pregnancy and newborn liver function. Chemosphere. 2019 Jul;226:447-453 Authors: Pejhan A, Agah J, Adli A, Mehrabadi S, Raoufinia R, Mokamel A, Abroudi M, Ghalenovi M, Sadeghi Z, Bolghanabadi Z, Bazghandi MS, Hamidnia M, Salimi F, Pajohanfar NS, Dadvand P, Rad A, Miri M Abstract Exposure to air pollution has been associated with a wide range of adverse health outcomes. However, the available evidence on the impact of air pollution exposures on liver enzymes is still scarce. The aim of the present study was to assess the relationship between exposure to ambient PM1, PM2.5 and PM10 during pregnancy and serum level of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) in cord blood samples of newborns. Moreover, the association between total street length in different buffers and distance to major roads at the maternal residential address and liver enzymes were investigated. This cross-sectional study was based on data from a sample of 150 newborns, from Sabzevar, Iran. Land use regression models were used to estimate concentrations of air pollutants at home during pregnancy. Multiple linear regression was developed to estimate association of AST, ALT, ALP and GGT with air pollution controlled for relevant covariates. In fully adjusted models, increase in PM1 and PM2.5 as well as PM10 were associated with higher levels of AST,...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research