Menopause exacerbates visual dysfunction in experimental glaucoma.

Menopause exacerbates visual dysfunction in experimental glaucoma. Exp Eye Res. 2019 Jun 18;:107706 Authors: Feola AJ, Fu J, Allen R, Yang V, Campbell IC, Ottensmeyer A, Ethier CR, Pardue M Abstract Glaucoma is the leading cause of irreversible blindness worldwide. Recently, estrogen deficiencies caused by early menopause, alterations in estrogen signaling via mutations in estrogen receptors, and polymorphisms along estrogen metabolic pathways have all been linked to an increased risk of developing glaucoma. Here, we examined how menopause and age impact visual function and retinal structure in an experimental model of glaucoma. Young (3-4 months) and aged (9-10 months) female Brown Norway rats were divided into pre- and post-menopausal cohorts by surgically inducing menopause via ovariectomy (OVX). After six weeks, ocular hypertension (OHT) was induced unilaterally for a period of eight weeks. Four cohorts were successfully followed to eight weeks: young sham (n = 8), young OVX (n = 9), aged sham (n = 10), and aged OVX (n = 11) animals. Intraocular pressure (IOP) was monitored weekly in all groups. Prior to inducing OHT (baseline) and at four and eight weeks after inducing OHT, we assessed visual acuity via the optomotor response (OMR) and retinal structure using optical coherence tomography (OCT). OHT decreased the OMR in all cohorts. We found that spatial frequency thresholds decreased by 54% in OVX animals after OHT compared to sham a...
Source: Experimental Eye Research - Category: Opthalmology Authors: Tags: Exp Eye Res Source Type: research

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Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Authors: Öztürk H, Özen B, Çatlı G, Dündar B Abstract Background: Macular damage may be observed in obesity and metabolic syndrome (MetS) that lead to chronic subclinical inflammation and affect almost all organ systems. Objectives: The purpose of this study was to investigate the relations of macular variability with anthropometric measurements, metabolic parameters, and inflammatory markers in children and adolescents with MetS. Methods: Two hundred twenty-eyes of 62 obese and 48 healthy children and adolescents were included in the study. Bilateral macular retinal thickness (M...
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research
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Source: Journal of Community Health - Category: International Medicine & Public Health Source Type: research
Spinal deformity in asolescent idiopathic scoliosis (AIS) can increase right atrial and ventricular pressures secondary to restrictive lung disease. Pulmonary hypertension leading to cor pulmonale is the most feared outcome. However, mild pulmonary hypertension in AIS patients has been reported in the past. No study has examined these changes including the improvement of right heart function following scoliosis surgery.
Source: The Spine Journal - Category: Orthopaedics Authors: Source Type: research
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Source: The Lancet - Category: General Medicine Source Type: research
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Source: JSLS : Journal of the Society of Laparoendoscopic Surgeons - Category: Surgery Tags: JSLS Source Type: research
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Source: J Korean Med Sci - Category: General Medicine Authors: Tags: J Korean Med Sci Source Type: research
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