The influence of a new derivate of kisspeptin-10 - kissorphin (KSO) on the rewarding effects of morphine in the conditioned place preference (CPP) test in male rats.

The influence of a new derivate of kisspeptin-10 - kissorphin (KSO) on the rewarding effects of morphine in the conditioned place preference (CPP) test in male rats.
Behav Brain Res. 2019 Jun 18;:112043
Authors: Gibula-Tarlowska E, Kedzierska E, Piechura K, Silberring J, Kotlinska JH
Abstract
Kissorphin (KSO) is a new peptide derived from kisspeptin-10. Previous study has indicated that this peptide displays neuropeptide FF (NPFF)-like anti-opioid activity. Herein, we examined the influence of KSO (1; 3, and 10 nmol, intravenously [i.v.]), on the rewarding action of morphine (5 mg/kg, intraperitoneally [i.p.]), using the unbiased design of the conditioned place preference (CPP) paradigm in rats. To test the effect of KSO on the acquisition of morphine-induced CPP, KSO and morphine were co-injected during conditioning with no drugs treatment on the test day. To investigate the effect of KSO on the expression of morphine-induced CPP, morphine alone was given during the conditioning phase (1 × 3 days) and KSO was administered 5 min prior to the placement in the CPP apparatus on the test day. To estimate the influence of KSO on the reinstatement of morphine-induced CPP, KSO was given 5 min before a priming dose of morphine (5 mg/kg, i.p.) on the reinstatement test day. The results show that KSO inhibited the acquisition, expression and reinstatement of morphine-induced CPP. The strongest effect of KSO was observed at the d...

Source: Behavioural Brain Research - June 17, 2019 Category: Neurology Authors: Gibula-Tarlowska E, Kedzierska E, Piechura K, Silberring J, Kotlinska JH Tags: Behav Brain Res Source Type: research