Inhibitory effects of oxymatrine on hepatic stellate cells activation through TGF- β/miR-195/Smad signaling pathway.
CONCLUSIONS: Given these results, OM could inhibit TGF-β1 induced activation of HSC-T6 proliferation in a dose-dependent and time-dependent manner to some extent. We proved that OM inhibited HSC activation through down-regulating the expression of miR-195 and up-regulating Smad7.
PMID: 31221141 [PubMed - in process]
Source: Methods of Information in Medicine - Category: Information Technology Authors: Song LY, Ma YT, Fang WJ, He Y, Wu JL, Zuo SR, Deng ZZ, Wang SF, Liu SK Tags: BMC Complement Altern Med Source Type: research