Electroacupuncture Mitigates Hippocampal Cognitive Impairments by Reducing BACE1 Deposition and Activating PKA in APP/PS1 Double Transgenic Mice.

This study examined the effects of electroacupuncture (EA) stimulation on BACE1, APP, and p-PKA protein levels in hippocampal tissue samples. Memory and learning abilities were assessed using the Morris water maze test after EA intervention. Immunofluorescence, immunohistochemistry, and western blot were employed to assess the distribution patterns and expression levels of BACE1, APP, and p-PKA, respectively. The results showed the downregulation of BACE1 and APP and the activation of PKA by EA. In summary, EA treatment might reduce BACE1 deposition in APP/PS1 transgenic mice and regulate PKA and its associated substrates, such as LTP to change memory and learning abilities. PMID: 31223308 [PubMed - in process]
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research

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CONCLUSIONS: Amyloid-PET positivity is associated with lower MoCA scores. Clinical utility of amyloid-PET scan is likely to be suboptimal at the MoCA score cutoff for minimal cognitive impairment. PMID: 31305321 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
Authors: Kapasi A, Yu L, Stewart CC, Schneider JA, Bennett DA, Boyle PA Abstract BACKGROUND: Low health and financial literacy may be an early behavioral manifestation of cognitive impairment, dementia, and accumulating Alzheimer pathology. However, there are limited studies investigating the behavioral features associated with hyperphosphorylated transactive response DNA-binding protein-43 (TDP-43), a common age-related pathology, and even fewer studies investigating the neurobiological basis underlying low literacy in aging. OBJECTIVE: To test the hypothesis that TDP-43 pathology is associated with lower lite...
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
(CNN) — Having a paying job might shield women from memory loss decades later, according to a new study. That’s because paid work may offer mental stimulation, financial benefits and social connections that could limit declines in memory as women age, said Elizabeth Rose Mayeda, who led the research as an assistant professor of epidemiology at UCLA’s Fielding School of Public Health. With women making up nearly two-thirds of all Americans living with Alzheimer’s, the research suggests that preventing the disease may require more than drugs or medical interventions. “Policies that promote equal...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Stay-At-Home Moms Source Type: news
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Source: Psychiatr News - Category: Psychiatry Tags: Association International Conference dementia Los Angeles older white adults sleep medications Source Type: research
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Source: Medscape Psychiatry Headlines - Category: Psychiatry Tags: Neurology & Neurosurgery News Source Type: news
Healthful eating and exercise might lower dementia risk in those who are genetically predisposed to developing Alzheimer ’s disease.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Alzheimer ' s Disease Dementia Genetics and Heredity Alcoholic Beverages Diet and Nutrition Exercise Source Type: news
Protein tau may spread more rapidly in female brains than males ’, adding to range of factorsThe reason women appear to be at greater risk of developing Alzheimer ’s disease than men might be due to a number of genetic, anatomical and even social influences, researchers have suggested.Recent figures show about 65% of those with living with dementia in the UK are women, with a similar statistic seen in the US for Alzheimer ’s disease, while dementia is theleading cause of death for women in England. Alzheimer ’s disease is only one of the types of dementia, but the most common form.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Alzheimer's Science Society Health Dementia Source Type: news
In this study, we aimed to investigate correlated structural and functional brain changes in AD and BD by combining resting-state functional magnetic resonance imaging (fMRI) and diffusion MRI. A group independent component analysis was first performed on the fMRI data to extract 49 intrinsic connectivity networks (ICNs). Then we conducted a multi-set canonical correlation analysis on three features, functional network connectivity (FNC) between ICNs, fractional anisotropy (FA) and mean diffusivity (MD). Two inter-correlated components show significant group differences. The first component demonstrates distinct brain chan...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
New research gives some biological clues to why women may be more likely than men to develop Alzheimer's disease and how this most common form of dementia varies by sex
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
Regardless of how much genetic risk someone has, a good diet, adequate exercise, limiting alcohol and not smoking made dementia less likely
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news
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