Impaired Glycoprotein VI-Mediated Signaling and Platelet Functional Responses in CD45 Knockout Mice.

CONCLUSION:  We conclude that the truncated CD45 isoform regulates GPVI-mediated signaling and platelet functional responses by regulating SFK activation.
PMID: 31226719 [PubMed - as supplied by publisher]

Source: Thrombosis and Haemostasis - June 20, 2019 Category: Hematology Authors: Inamdar VV, Kostyak JC, Badolia R, Dangelmaier CA, Manne BK, Patel A, Kim S, Kunapuli SP Tags: Thromb Haemost Source Type: research