Management of psoriasis as a systemic disease: What is the evidence?

CONCLUSIONS: Results from ongoing prospective studies on the effects of biologics on markers of systemic inflammation in patients with psoriasis will strengthen the clinical evidence base that can be used to inform treatment decisions for patients with moderate-to-severe psoriasis. PMID: 31225638 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research

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ConclusionsRemission of type 2 diabetes 5 years after bariatric surgery was associated with improvements in albuminuria and stabilized prognostic risk for CKD, but not with eGFR. Lower kidney function and greater prognostic risk at the time of bariatric surgery was linked to a lower likelihood of diabetes remission. These results highlight the need to identify the mechanisms through which bariatric surgery may delay the long-term progression of CKD in type 2 diabetes.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
Publication date: Available online 19 July 2019Source: European Journal of RadiologyAuthor(s): Claire Boudinaud, Armand Abergel, Juliette Joubert-Zakeyh, Mikael Fontarensky, Bruno Pereira, Benoit Chauveau, Jean Marc Garcier, Pascal Chabrot, Louis Boyer, Benoît MagninAbstractPurposeGiven the growing prevalence of obesity and metabolic syndrome, the management of hepatic steatosis, especially its quantification, is a major issue. We assessed the quantification of liver steatosis using four different MR methods, in order to determine the one that is best correlated with the reference method which consists of histologica...
Source: European Journal of Radiology - Category: Radiology Source Type: research
CONCLUSIONS: Steroid receptor coactivators are critical regulators of human metabolism with pleiotropic and tissue-specific actions. We believe that our study will contribute to the better understanding of the complex multi-tissue interactions that are disrupted in obesity and can therefore lead in numerous cardiometabolic diseases. Further on, present findings suggest that SRC-3/AIB-1 could constitute possible future drug targets. PMID: 31322077 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
Authors: Hamouda L, Miliani M, Hadjidj Z, Messali R, Aribi M Abstract BACKGROUND: Monocytes are the main blood innate mononuclear phagocyte and one of the most important effector cells expressing Fcγ receptor, which is critical for the interaction with Fc domain of antibodies. OBJECTIVE: To evaluate the effect of Rituximab (RTX, a chimeric human anti-CD20 monoclonal antibody) on the functional activities of Monocytes (MOs) at the onset of human Type 1 Diabetes (T1D). METHODS: MOs were isolated from peripheral blood mononuclear cells (PBMCs) obtained from volunteer patients with recent-onset T1D and he...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
Authors: Wykretowicz M, Katulska K, Zwanzig M, Krauze T, Piskorski J, Guzik P, Wykretowicz A Abstract OBJECTIVES: Left atrial fibrosis represents a substrate for atrial fibrillation (AF) and cardioembolic events. White matter hyperintensities (WMH) are commonly found on magnetic resonance imaging (MRI) and are regarded, at least partly as ischemic brain lesions. Aortic excess pressure (excessPTI) represents an extra work performed by the left ventricle and is a new risk metric associated with cardiovascular complications. The aim of our study was to assessed whether there is a correlation between the degree of LA f...
Source: Scandinavian Cardiovascular Journal - Category: Cardiology Tags: Scand Cardiovasc J Source Type: research
Publication date: August 2019Source: Nutrition, Metabolism and Cardiovascular Diseases, Volume 29, Issue 8Author(s): Ilaria Calabrese, Marilena Vitale, Maria Masulli, Angela Albarosa Rivellese, Gabriele Riccardi, Olga Vaccaro
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Publication date: August 2019Source: Nutrition, Metabolism and Cardiovascular Diseases, Volume 29, Issue 8Author(s): Augusto Di Castelnuovo, Simona Costanzo, Marialaura Bonaccio, Patrick McElduff, Allan Linneberg, Veikko Salomaa, Satu Männistö, Marie Moitry, Jean Ferrières, Jean Dallongeville, Barbara Thorand, Hermann Brenner, Marco Ferrario, Abdonas Tamosiunas, Inger Njølstad, Wojciech Drygas, Yuriy P Nikitin, Stefan Söderberg, Frank Kee, Tanja Zeller
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Publication date: August 2019Source: Nutrition, Metabolism and Cardiovascular Diseases, Volume 29, Issue 8Author(s): Giuseppe Iacomino, Paola Russo, Pasquale Marena, Fabio Lauria, Antonella Venezia, Nunzia Iannaccone, Wolfgang Ahrens, Stefaan De Henauw, Pasquale De Luca, Ronja Foraita, Kathrin Günther, Lauren Lissner, Dénes Molnár, Luis A Moreno, Michael Tornaritis, Toomas Veidebaum, Alfonso Siani
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Publication date: October 2019Source: Journal of Functional Foods, Volume 61Author(s): Yang Yu, Zuogong Zhao, Tiehu Liu, Hua Wan, Dongnan QiAbstractThe present study investigated the protective effect of L-cysteine on biomarkers and peripheral nervous system in streptozotocin-induced diabetic rats. The experimental groups included sham, control, 0.1 mM cysteine treatment, and 0.2 mM cysteine treatment. Behavioral assessment, fasting glucose, lipid peroxidation, glutathione peroxidase, superoxide dismutase, and catalase activities, as well as reduced GSH, tumor necrosis factor (TNF), -α, interleukin-6 (IL-6), inte...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Publication date: Available online 19 July 2019Source: Brain, Behavior, and ImmunityAuthor(s): Mireia Adelantado-Renau, Irene Esteban-Cornejo, María Rodriguez-Ayllon, Cristina Cadenas-Sanchez, Jose Juan Gil-Cosano, Jose Mora-Gonzalez, Patricio Solis-Urra, Juan Verdejo-Román, Concepción M. Aguilera, María Victoria Escolano-Margarit, Antonio Verdejo-Garcia, Andrés Catena, Diego Moliner-Urdiales, Francisco B. OrtegaAbstractIntroductionChronic inflammation plays an important role on the pathogenesis of several cardiovascular and metabolic diseases, as well as on brain function and behaviour. ...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
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