Chlamydia pneumonia – induced mucositis

A 16-year-old healthy male presented to the emergency department with a 5-day history of upper respiratory symptoms, persistent fever, and blisters present within the oral cavity. Two days before presentation, he also developed severe bilateral conjunctivitis with watery discharge. There were no other symptoms such as respiratory distress, skin rash, and genital lesions. He was not sexually active and denied taking any medications recently. His vitals were within normal limits. However, he appeared to be in distress that was secondary to pain.
Source: Pediatrics and Neonatology - Category: Perinatology & Neonatology Authors: Tags: Letter to the Editor Source Type: research

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We conducted a questionnaire survey among baseball players at junior high schools across Japan, to understand the practice conditions of players, examining the risk factors of shoulder and elbow pain in baseball players.
Source: Journal of Shoulder and Elbow Surgery - Category: Orthopaedics Authors: Source Type: research
Rotator cuff tears (RCTs) are often associated with severe shoulder pain. However, the mechanism of pain in RCTs is still unknown. In recent years, it has been reported that various neuropeptides, including calcitonin gene-related peptides (CGRP), are involved in knee and hip pain. To reveal the novel mechanism for pain caused by RCTs, we investigated the expression of neuropeptides in a rat RCT model.
Source: Journal of Shoulder and Elbow Surgery - Category: Orthopaedics Authors: Source Type: research
Mesenchymal stem cells (MSCs) possess anti-inflammatory properties and tissue differentiation potential. We prepared a rat shoulder arthritis model by injecting monoiodoacetate (MIA) into the shoulder and investigated the intraarticular administration of MSCs from the aspects of the cartilage protective effect associated with the cell ’s anti-inflammatory activity and inhibition of the central sensitization of pain. When MIA was administered in this model, anti-calcitonin gene related peptide (CGRP) was expressed in the shoulder joint and C5 spinal dorsal horn.
Source: Journal of Shoulder and Elbow Surgery - Category: Orthopaedics Authors: Source Type: research
Abstract Humoral immunological defects are frequent and important causes of hypogammaglobulinemia, leading to recurrent infections, autoimmunity, allergies, and neoplasias. Usually, its onset occurs in childhood or during the second and third decades of life; however, the diagnosis is made, on average, 6 to 7 years afterwards. As a consequence, antibody defects can lead to sequelae. Here we describe the clinical-laboratory characteristics, treatment, and prognoses of patients with hypogammaglobulinemia. An observational, cross-sectional, and retrospective study of patients attending the recently established outpat...
Source: Braz J Med Biol Res - Category: Research Authors: Tags: Braz J Med Biol Res Source Type: research
This article provides a review of the preclinical and clinical pharmacology of lorcaserin, including its pharmacokinetic and safety profiles. Preclinical studies with lorcaserin initially focused on simple measures of food intake and body weight gain, but have now expanded to include studies on its effects on appetitive aspects of feeding behaviour and models of binge-eating. A significant number of studies have also shown that lorcaserin alters behaviours related to drug use and addiction, in rodents and non-human primates. Potential clinically-relevant effects of lorcaserin have also been reported in models of pain and s...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
ConclusionThe anti-inflammatory effects of X. aethiopica leaves are demonstrated experimentally, thus substantiating its use in folk Medicine. Relevantly, the observed anti-inflammatory properties can stimulate further studies in order to fully unveil the therapeutic potential of the plant, namely as sources of phenolic compounds with a significant ability to interfere with conventional inflammatory targets.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Abstract The species Kalanchoe laciniata (L.) DC. and Bryophyllum pinnatum (Lam) Pers. are native from Brazil and Madagascar, respectively. Both belonging to the Crassulaceae family and being widely used by population as a natural anti-inflammatory agent. These species have similar leaf morphology and for this reason, they are known by the same popular name as “ sai ão ” or “ coirama ” . Several studies have been published involving different parts and preparations of these species. Therefore, this review aims to provide an update overview about the traditional uses, chemical constitution, ph...
Source: Revista Brasileira de Farmacognosia - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 16 October 2019Source: Anaesthesia Critical Care &Pain MedicineAuthor(s): M.S. Raghuraman, A. Arthi, M.S. Iswaryarajan Hercule
Source: Anaesthesia, Critical Care and Pain Medicine - Category: Anesthesiology Source Type: research
ConclusionThis study showed that calcitonin could be helpful analgesic agent in different painful situations. Calcitonin can be considered an eligible treatment for acute pains related to vertebral fractures and a feasible alternative for the treatment of the acute and chronic neuropathic pains where other medications might fail.ResumoJustificativa e objetivosA calcitonina é um hormônio polipeptídico que regula o metabolismo do cálcio no organismo. Por muitos anos a calcitonina tem sido usada para manter e melhorar a densidade mineral óssea e reduzir a incidência de fraturas. Muitos ...
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
CONCLUSIONS: Treatment with antibacterial agents achieves microbiological cure from C.trachomatis infection during pregnancy. There was no apparent difference between assessed agents (amoxicillin, erythromycin, clindamycin, azithromycin) in terms of efficacy (microbiological cure and repeat infection) and pregnancy complications (preterm birth, preterm rupture of membranes, low birthweight). Azithromycin and clindamycin appear to result in fewer side effects than erythromycin.All of the studies in this review were conducted in North America, which may limit the generalisability of the results. In addition, study population...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
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