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Orencia® (abatacept) 125mg solution for injection - New Formulation

Source: eMC (electronic Medicines Compendium) Area: Other Library Updates> SPC Changes Bristol-Myers Squibb has been granted marketing authorisation for a new formulation given by subcutaneous injection.   Orencia® (abatacept) in combination with methotrexate is indicated for the treatment of moderate to severe active rheumatoid arthritis in adult patients who responded inadequately to previous therapy with one or more disease-modifying anti-rheumatic drugs including methotrexate or a tumour necrosis factor-alpha inhibitor.   Please see link to SPC for full prescribing information.
Source: NeLM - SPC Changes - Category: Drugs & Pharmacology Source Type: news

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In this study, we intended to find the effect of T-614 on the osteogenesis process. We detected osteogenesis markers and transcription factors associated with osteoblastic lineage and bone formation in the culture of mesenchymal stem cells which differentiate osteoblast. The contents and activity of alkaline phosphatase, levels of collagen type I and bone gla protein, and calcium nodule formation were increased significantly after T-614 treated. Meanwhile, the mRNAs expressions of Osterix and Dlx5 were also found to be increased significantly by real-time PCR. The changes of levels of phosphorylation of p38 and NF-κB...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Conclusions: The increased anti-P-gp effect of MTX + 4-HC versus MTX alone in RA-FLSs was mediated via inhibition of the JAK2/STAT3 pathway and may have helped reverse MDR in refractory RA patients with high-P-gp levels. PMID: 29670920 [PubMed - in process]
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
ConclusionBaricitinib 4  mg was efficacious compared to placebo in US and ROW subpopulations. Safety was similar between subgroups.FundingEli Lilly&Company and Incyte Corporation.Trial RegistrationClinicalTrials.gov identifiers, NCT01721057; NCT01710358.
Source: Rheumatology and Therapy - Category: Rheumatology Source Type: research
AbstractWe compared the change in joint inflammation and the proportion of subjects achieving threshold levels of improvement using the existing methods employing ultrasonography on pre-determined joint sites versus novel methods. These novel methods select the most affected joints based on (i) ultrasonography —the Individualized-Ultrasound (IUS) method, or (ii) ultrasonography and clinical joint assessment—the individualized-Composite-Ultrasound (ICUS) method. Mean 3-month change in total inflammation score (ΔTIS) and 95% CI was computed for each method on 24 RA subjects initiated or escalated on tr eatm...
Source: Rheumatology International - Category: Rheumatology Source Type: research
In this report, we presented a case of RA presenting with cervical spine involvement without peripheral arthritis to underline the importance of this kind of involvement in clinical practice. We also briefly reviewed other cases similar to ours in light of literature.
Source: Rheumatology International - Category: Rheumatology Source Type: research
Authors: Ling S, Bluett J, Barton A PMID: 29667454 [PubMed - as supplied by publisher]
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
An experimental rheumatoid arthritis drug developed by Eli Lilly and Co and Incyte Corp poses serious risks of deadly blood clots at higher doses, U.S. Food and Drug Administration staff said on Thursday, the latest setback to a treatment regulators declined to approve last year.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news
RHEUMATOID arthritis, and other forms of the disease, cause pain and discomfort among other symptoms. There is no cure, but can be treated using lifestyle changes, diet alterations and medication. Try using this neat trick to reduce pain caused by a flare-up.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
First bit of news: I’ve had absolutely no pain in my heel. It’s as good as new. I have to admit I’m still stunned…and I wonder if a more conventional doctor, let’s say a physiotherapist, would have made the connection between my relatively new eyeglass prescription and my heel pain. I doubt it. This makes me wonder how many similar cases there are, of people who think they have plantar fasciitis or tendonitis or, sorry for the mention!  , heel spurs, but whose pain actually originated in a different part of the body, an easy-to-fix part of the body. Mind-blowing, eh? But the reason I&rsq...
Source: Margaret's Corner - Category: Cancer & Oncology Authors: Tags: Blogroll celiac disease curcumin EBV Epstein-Barr virus inflammatory bowel disease lupus multiple sclerosis rheumatoid arthritis type 1 diabetes Source Type: blogs
This study aimed to assess the utility of thermographic imaging in the evaluation of inflammatory arthritis activity as an adjunct to clinical assessment. This was a cross-sectional study of 79 subjects recruited from the University of Alberta Outpatient Rheumatology clinic comparing the hand joints of 49 patients with rheumatoid arthritis (RA) diagnosed by American College of Rheumatology (ACR) criteria to 30 healthy volunteers. Convenience sampling of consecutive RA patients was undertaken. The effect of clinical assessment (HAQ and DAS-28) on joint temperature was evaluated using a linear mixed effect model. A thermogra...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
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