Log in to search using one of your social media accounts:

 

Orencia® (abatacept) 125mg solution for injection - New Formulation

Source: eMC (electronic Medicines Compendium) Area: Other Library Updates> SPC Changes Bristol-Myers Squibb has been granted marketing authorisation for a new formulation given by subcutaneous injection.   Orencia® (abatacept) in combination with methotrexate is indicated for the treatment of moderate to severe active rheumatoid arthritis in adult patients who responded inadequately to previous therapy with one or more disease-modifying anti-rheumatic drugs including methotrexate or a tumour necrosis factor-alpha inhibitor.   Please see link to SPC for full prescribing information.
Source: NeLM - SPC Changes - Category: Drugs & Pharmacology Source Type: news

Related Links:

CONCLUSIONS: Our studies show that ACPA-IgG1 IC bind predominately to activating FcγRI and FcγRIIIA, and highlight FcγRI expressed by activated neutrophils as relevant receptor for these IC. As neutrophils isolated from SF exhibit an activated state and express FcγRI in the synovial compartment, this IC-binding could contribute to driving disease pathogenesis in RA. PMID: 29352854 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Authors: Bo M, Erre GL, Niegowska M, Piras M, Taras L, Longu MG, Passiu G, Sechi LA Abstract OBJECTIVES: Rheumatoid arthritis (RA) is a chronic disease characterised by a pro-inflammatory cytokines linked erosive joint damage and by humoral and cellular response against a broad range of self-peptides. Molecular mimicry between Epstein-Barr virus (EBV), Mycobacterium avium subsp. paratuberculosis (MAP) and host peptides has long been regarded as an RA pathogenetic mechanism. Using bioinformatic analysis we identified high sequence homology among interferon regulatory factor 5 (IRF5), EBV antigen BOLF1 and MAP antige...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
CONCLUSIONS: JAK/STAT activation plays a pivotal role in TNF-α-mediated GLS up-regulation in RA. Suppression of GLS expression in FLSs has been suggested to be one of the mechanisms through which tofacitinib exerts its anti-inflammatory effects. PMID: 29352846 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
The objective of this study was a health economic assessment in Italy. METHODS: The study was conducted using a pharmacoeconomic model with a 3-year time horizon. Effectiveness was measured as days gained in low disease activity (LDA; DAS28-ESR
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
CONCLUSIONS: IR in RA does not appear to be mediated by amylin. This would imply that the mechanisms associated with IR in RA patients differ from those at work in type 2 diabetes. PMID: 29352842 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Authors: Lei X, Li H, Zhan Y, Qu J Abstract OBJECTIVES: To investigate the clinical value of dynamic contrast-enhanced MRI (DCE-MRI) and laboratory indexes in predicting conversion from undifferentiated arthritis (UA) to rheumatoid arthritis (RA). METHODS: A total 81 DMARD-naive UA patients were studied. 37 cases were ultimately diagnosed as RA, 32 cases were diagnosed as other types of arthritis, and the remaining cases were still UA during the 1-year follow-up. The DCE-MRI and laboratory measures were fed into a logistic regression analysis. RESULTS: Wash-in rate and anti-cyclic citrullinated peptide (ant...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Source: BMJ News - Category: General Medicine Source Type: research
You're reading 7 Reasons To Meditate, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. Do you always feel tired, stressed, and angry? Are you impulsive and can`t seem to stop snapping at people for the wrong reasons? If you say Yes, then you have to meditate more often. Why You Must Meditate Meditation is one of the best physical and spiritual activities you can gift yourself. For just 10 minutes each day, you can improve your mood, boost your energy and increase tranquility. But it`s not just about that. Researchers have ...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured health and fitness psychology self improvement alzheimer's health benefits of meditation meditate pickthebrain sleep aid Source Type: blogs
Liuqing Di A sensitive and rapid ultra high-performance liquid-chromatography tandem mass spectrometry (UHPLC-MS/MS) method has been applied to investigate the influence of rheumatoid arthritis (RA) on the pharmacokinetics of nine analytes (daphnetin, daphnoretin, 7-hydroxycoumarin, liquiritin, isoliquiritin, liquiritigenin, isoliquiritigenin, glycyrrhizin, and glycyrrhetinic acid), which are major active components in Zushima-Gancao extract. The analytes and internal standard (IS) were separated in a Hypersil Gold C18 column and detected on a triple-stage quadrupole mass spectrometer using the validated method. All...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Hello, this is my first post. I'm from Chile and I'm in my first year of internship. Once a Rheumatologist told us to not starting prednisone in rheumatoid arthritis suspicion (we don't have access to DMARDs as general practitioners) because at time of referral there will be no objective clinical or laboratory signs of active disease so it would be more difficult to do the differential, so his suggestion was to start only NSAIDs and early referral (although it takes a pair of months here,... Rheum: Starting prednisone on suspected conditions as initial treatment question
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Source Type: forums
More News: Abatacept | Arthritis | Databases & Libraries | Drugs & Pharmacology | Marketing | Methotrexate | Orencia | Rheumatoid Arthritis | Rheumatology