Investigation of Soret effect on drug delivery in a tumor without necrotic core

Publication date: Available online 21 June 2019Source: Journal of the Taiwan Institute of Chemical EngineersAuthor(s): Farzin H. Vazifehshenas, Fatemeh BahadoriAbstractOne of the main challenges in cancer therapy is the presence of high interstitial pressure within the tumor's center which creates significant resistance opposite chemotherapy. In the present study, Soret effect has been introduced in order to overcome the physicochemical and biological barriers involved in drug delivery into the targeted cells. Three main transport phenomena have been studied in the present research for the purpose of tumor modeling: (A) macroscopic fluid transfer, (B) macroscopic mass transfer and (C) bio-heat transfer. The continuity, momentum and bio-heat transfer equations have been solved steadily, while mass transfer equations have been solved unsteadily regarding diffusion and convection effects through the cellular and extracellular tissues. The pressure, velocity, and temperature distribution relations have been obtained by solving the relevant equations analytically, while the concentration distribution profiles have been obtained numerically. It was observed that the tumor temperature is greater than normal tissue temperature up to 3 °C. For this temperature gradient, Sr calculated by −0.04. According to Soret effect, the drug with molecular weight tends to moves to the cold region. So, different Soret numbers of −0.01, −0.04, −0.1, 0, 0.01, and 0.1 was evaluated to deter...
Source: Journal of the Taiwan Institute of Chemical Engineers - Category: Chemistry Source Type: research