Design, synthesis and anti-diabetic activity of chromen-2-one derivatives

Publication date: July 2019Source: Arabian Journal of Chemistry, Volume 12, Issue 5Author(s): Rina Soni, Sunil Dutt Durgapal, Shubhangi S. Soman, John J GeorrgeAbstractDPP-IV inhibitors have been immersed as promising pathway to treat Type 2 diabetes. Here we have reported designing of coumarin derivatives as DPP-IV inhibitors. Designed compounds have been studied for their binding with DPP-IV enzyme through molecular docking followed by synthesis. All synthesized compounds have been fully characterized and screened for DPP-IV inhibition activity. Two compounds showed very good inhibition at 10 μM concentration.
Source: Arabian Journal of Chemistry - Category: Chemistry Source Type: research