Pain inhibition by opioids-new concepts.

CONCLUSION: The epidemic of opioid misuse has shown that there is a lack of fundamental knowledge about the characteristics and management of chronic pain, that conflicts of interest and validity of models must be more intensively considered in the context of drug development and that novel analgesics with less addictive potential are urgently needed. Currently, the most promising perspectives appear to be augmenting endogenous opioid actions and the selective activation of peripheral opioid receptors. PMID: 31222410 [PubMed - as supplied by publisher]
Source: Schmerz - Category: Anesthesiology Authors: Tags: Schmerz Source Type: research

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Surface channel waveguides (WGs) based on a half-ring (40 – 60- µ m-diameter) depressed-index cladding (type III) geometry are ...
Source: Optics Letters - Category: Physics Authors: Source Type: research
The objective of this study was to evaluate the preoperative anxiety of hospitalized patients exposed to Spiritist “passe,” laying on of hand with the intention of healing (Sham) and without laying on of hand. Other variables as depression, pain, physiological parameters, muscle tension, and well-being were assessed. Patients in the Spiritist “passe” intervention group showed greater reductions in anxiet y (p 
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New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0NJ02844D, PaperMuhammad Khattab, Ahmed A. Al-Karmalawy Preclinical and clinical studies on Mebendazole revealed its potential as anticancer agent. We therefore aimed to investigate its binding interactions with one of the most important cancer targets (Tubulin protein)... The content of this RSS Feed (c) The Royal Society of Chemistry
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Cases rise by over 230,000 worldwide in 24 hours; 250,000 people in Manila to return to lockdown; Brazil cases near 2m‘Compelling’ evidence air pollution worsens coronavirus – studyGerman study finds low Covid-19 infection rate in schoolsFauci sidelined as Trump ’s White House steps up briefing campaignBereaved urge EU chief to supervise Italian coronavirus inquiry7.57pmBSTThe Trump administration is increasinglyat war with Anthony Fauci, the federal government ’s top public health expert, over the handling of the epidemic, as the US continues to report around 60,000 new cases a day.In what ap...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak World news US news UK news Australia news South Africa Brazil Science Infectious diseases Source Type: news
Mice that experienced heart attacks underwent a large-scale shift in their immune systems that allowed cancer to flourish, perhaps explaining the observation in patients.
Source: The Scientist - Category: Science Tags: News & Opinion Source Type: news
Conclusion: Our results may help decisionmakers in countries in relatively early stages of the epidemic, especially Brazil, understand the importance of control measures in decelerating the growth curve of confirmed cases.
Source: Revista Brasileira de Terapia Intensiva - Category: Intensive Care Source Type: research
Conclusion: In this cohort of patients with esophageal cancer admitted to intensive care units with acute illness, the in-hospital mortality rate was very high. The requirement for invasive mechanical ventilation and metastatic disease were independent prognostic factors and should be considered in discussions about the short-term outcomes of these patients.
Source: Revista Brasileira de Terapia Intensiva - Category: Intensive Care Source Type: research
Loss of chromosome Y (LOY) is a mosaic aneuploidy that can be detected mainly in blood samples of male individuals. Usually, LOY occurrence increases with chronological age in healthy men. Moreover, recently LOY has been reported in association with several diseases, such as cancer, where its frequency is even higher. The Y chromosome is one of the shortest chromosomes of the human karyotype, and it is crucial for correct male development. This chromosome has functions beyond the male reproductive system, and loss of its genes or even LOY can have consequences for the male body that are yet to be elucidated. Analyses of th...
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This article reviews pharmacological principles and research strategies aiming at novel opioids with reduced side effects. Basic mechanisms underlying pain, opioid analgesia and other opioid actions are outlined. To illustrate the clinical situation and medical needs, plasticity of opioid receptors, intracellular signaling pathways, endogenous and exogenous opioid receptor ligands, central and peripheral sites of analgesic and side effects are discussed. Expert opinion: The epidemic of opioid misuse has taught us that there is a lack of fundamental knowledge about the characteristics and management of chronic pain, that co...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
  RX PAD With the death of the entertainer Prince attributed to a fentanyl overdose, and new FDA warnings, opioids have been making headlines. Since the most common reason patients visit the emergency department is for pain, it is not surprising that emergency physicians prescribe and administer medications such as oxycodone on a daily basis. Here are some of the basics about how oxycodone works, and also the reason why chronic users may be at even higher risk of unexpected respiratory depression. HOW IT WORKS: Oxycodone is a semi-synthetic opioid with analgesic properties. Oxycodone binds to mu, kappa, and delta opio...
Source: EPMonthly.com - Category: Emergency Medicine Authors: Tags: Uncategorized Source Type: news
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