Polymorphisms in GSTM1 and GSTT1 influence the response and treatment outcome in lung cancer patients treated with platinum-based chemotherapy.

CONCLUSION: The present study found no association of GSTT1 and GSTM1 with the overall survival in LC patients, however our data shows that patients carrying the GSTM1 genotype had a good response when treated with platinum-based doublet chemotherapy, therefore suggesting that GSTM1 polymorphism plays an important role in influencing the chemotherapy outcome and response in patients with lung cancer. PMID: 31218944 [PubMed - as supplied by publisher]
Source: British Journal of Biomedical Science - Category: Laboratory Medicine Tags: Br J Biomed Sci Source Type: research