Live attenuated influenza vaccines for African children

Publication date: Available online 21 June 2019Source: The Lancet Respiratory MedicineAuthor(s): Cheryl Cohen, Sheena G Sullivan
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research

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TUESDAY, July 16, 2019 -- Providing an educational handout about influenza disease in the waiting room before a pediatric provider visit may increase receipt of child influenza vaccine, according to a study published online July 8 in...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Conclusions: In addition to preventing influenza in 50% of participants, IIV4 attenuated illness severity and disease burden in children who had a breakthrough influenza episode despite vaccination.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Vaccine Reports Source Type: research
After the initial identification of the H1N1 pandemic influenza strain in Mexico in April 2009 and its subsequent global spread, several monovalent influenza vaccines were developed as part of the pandemic response. Three of these vaccines, Pandemrix, Arepanrix and Focetria were adjuvanted. One of these, the AS03-adjuvanted Pandemrix vaccine, was primarily used in Europe. Following widespread Pandemrix vaccine administration in Scandinavia, an increased risk of narcolepsy was noted in observational studies. Subsequently, this increased risk was also reported in other European countries as well. In contrast, studies from Ca...
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Vaccine Reports Source Type: research
Coming off rapid expansion in Holly Springs, a drugmaker has earned bragging rights for the first to manufacture influenza vaccines this year – setting up favorable contract negotiations for next year.
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Given that continuing antigenic shift and drift of influenza A viruses result in the escape from previous vaccine-induced immune protection, a universal influenza vaccine has been actively sought. However, there were very few vaccines capable of eliciting cross-group ant-influenza immunity. Here, we designed two novel composite immunogens containing highly conserved T-cell epitopes of six influenza A virus internal antigens, and expressed them in DNA, recombinant adenovirus-based (AdC68) and recombinant vaccinia vectors, respectively, to formulate three vaccine forms. The introduction of the two immunogens via a DNA primin...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
In conclusion, co-infection of chicks with AIV and IBV, simultaneously or sequentially, affected the clinical signs, the virus replication dynamics as well as the internal organ integrity. The results proposed that infection with heterologous virus may result in temporary competition for cell receptors or competent cells for replication, most likely interferon-mediated. PMID: 31300117 [PubMed - in process]
Source: Comparative immunology, microbiology and infectious diseases. - Category: Allergy & Immunology Authors: Tags: Comp Immunol Microbiol Infect Dis Source Type: research
In conclusion, oral administration of 1% IMU for six weeks can enhance the immune response after AI-H9N2 vaccination and reduce the pathogenicity of infection in stressed chickens. PMID: 31300109 [PubMed - in process]
Source: Comparative immunology, microbiology and infectious diseases. - Category: Allergy & Immunology Authors: Tags: Comp Immunol Microbiol Infect Dis Source Type: research
Publication date: August 2019Source: The Lancet Global Health, Volume 7, Issue 8Author(s): You Li, Rachel M Reeves, Xin Wang, Quique Bassat, W Abdullah Brooks, Cheryl Cohen, David P Moore, Marta Nunes, Barbara Rath, Harry Campbell, Harish Nair, RSV Global Epidemiology Network, Sozinho Acacio, Wladimir J Alonso, Martin Antonio, Guadalupe Ayora Talavera, Darmaa Badarch, Vicky L Baillie, Gisela Barrera-Badillo, Godfrey Bigogo, Shobha BroorSummaryBackgroundInfluenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus are the most common viruses associated with acute lower respiratory infections in young children (
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
Contributors : R E Drury ; D O'Connor ; A PollardSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensTo describe vaccine associated changes in the expression of microRNAs 21 days after vaccination in children receiving one of two pandemic influenza (H1N1) vaccines.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens Source Type: research
Publication date: Available online 11 July 2019Source: Veterinary MicrobiologyAuthor(s): Jiayun Yang, Zhengxiang Wang, Yingying Du, Yane Jia, Liang Wang, Shuai Xu, Qiyun ZhuAbstractDuring 2012―2015, six H5N1 avian influenza viruses were isolated from domestic birds and the environment around Qinghai Lake. Phylogenetic analysis of HA genes revealed that A/chicken/Gansu/XG2/2012 (CK/GS/XG2/12) belonged to clade 2.3.2.1a, while A/environment/Qinghai/1/2013 (EN/QH/1/13), A/chicken/Qinghai/QH1/2015 (CK/QH/QH1/15), A/chicken/Qinghai/QH2/2015 (CK/QH/QH2/15), A/chicken/Qinghai/QH3/2015 (CK/QH/QH3/15), and A/goose/Qinghai/QH6/201...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
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