Study of KRYSTEXXA ® (Pegloticase) Plus Methotrexate in Patients With Uncontrolled Gout

Condition:   Gout Interventions:   Biological: Pegloticase with MTX;   Biological: Pegloticase with placebo for MTX Sponsor:   Horizon Pharma Rheumatology LLC Recruiting
Source: - Category: Research Source Type: clinical trials

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In this study, we found that the proportion of CD14-positive PBMCs was decreased in gout patients when compared with healthy controls and the serum sCD14 level was also considerably decreased in gout patients in comparison to healthy controls. In addition, sCD14 levels were positively correlated with CRP levels. Furthermore, the effect of MSU on the levels of CD14 in healthy volunteer's PBMC was explored in in vitro experiment. The results showed that CD14 expression on macrophage and sCD14 levels in the culture supernatants were significantly decreased after MSU treatment. However, there was no significance in the levels ...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
A study to evaluate the prevalence of uric acid (UA) nephrolithiasis with dual-energy CT (DECT) and explore the risk factors for kidney stones in primary gout patients.
Source: BMC Nephrology - Category: Urology & Nephrology Authors: Tags: Research article Source Type: research
Does lowering of uric acid in gout lead to cardiovascular and renal benefits? A new study investigates the pathogenic impact of uric acid levels on CVD and CKD risk, but much is still unclear.European Heart Journal
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news
ConclusionUric acid ‐lowering therapy benefits hyperlipidemia in gouty patients. Febuxostat effectively improved serum cholesterol and triglyceride levels compared to allopurinol and benzbromarone in patients with gout.
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Publication date: Available online 14 July 2019Source: Pharmacological ResearchAuthor(s): Federica Raucci, Asif J. Iqbal, Anella Saviano, Paola Minosi, Marialuisa Piccolo, Carlo Irace, Francesco Caso, Raffaele Scarpa, Stefano Pieretti, Nicola Mascolo, Francesco MaioneAbstractGout is a paradigm of acute, self-limiting inflammation caused by the deposition of monosodium urate (MSU) crystals within intra-and/or peri-articular areas, which leads to excruciating pain, joint swelling and stiffness. The infiltration of leukocytes drives the inflammatory response and remains an attractive target for therapeutic intervention. In th...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Study indicates that wearing hearing aids could boost aspects of memory and attention in healthy older people Related items fromOnMedica Virtual reality could help spot Alzheimer ’s quicker Dementia leading cause of death in women over 80 Risk of Alzheimer ’s lower in people with gout WHO issues guidelines on dementia risk reduction LGBT community at higher risk of cognitive decline
Source: OnMedica Latest News - Category: UK Health Source Type: news
MONDAY, July 15, 2019 -- More than one-fourth of patients with acute gout discharged from the emergency department receive an opioid prescription, according to a study published online July 2 in Arthritis Care&Research. Deepan S. Dalal, M.D.,...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
Abstract We read with interest the recent study by Dehlin and colleagues1, investigating the validity of a gout diagnosis in primary care. We have also investigated how a primary care diagnosis of gout compares to a primary care diagnostic rule for gout and to classification criteria. Our objective was to determine the proportion of patients with a primary care diagnosis of gout who fulfilled the primary care diagnostic rule by Janssens, et al for acute gouty arthritis2 and the 1977 American Rheumatism Association (ARA) criteria for the classification of acute arthritis of primary gout3. PMID: 31308214 [PubMe...
Source: J Rheumatol - Category: Rheumatology Authors: Tags: J Rheumatol Source Type: research
Abstract OBJECTIVE: To examine whether a change in the presentation of incident gout happened over the last 20 years and to determine the risk of subsequent gout flares after an initial gout attack. METHODS: All incident cases of gout were identified among residents of Olmsted County, Minnesota diagnosed in 1989-1992 and 2009-2010 according to the earliest date fulfilling the 1977 American Rheumatism Association preliminary criteria, New York or Rome criteria for gout. Patients in both cohorts were then followed for up to five years. Cumulative incidence and personyear methods were used to compare flare rates...
Source: J Rheumatol - Category: Rheumatology Authors: Tags: J Rheumatol Source Type: research
Abstract It was with great interest that we read the letter from Watson and colleagues1 describing their investigation of how a primary care diagnosis of gout compares to a primary care diagnostic rule for gout and the 1977 American Rheumatism Association (ARA) classification criteria of acute arthritis of primary gout. They present positive predictive values (PPV) of 74% for the diagnostic rule and 80% for the ARA criteria. PMID: 31308204 [PubMed - as supplied by publisher]
Source: J Rheumatol - Category: Rheumatology Authors: Tags: J Rheumatol Source Type: research
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