Development and internal validation of a multinomial NTCP model for the severity of acute dyspnea after radiotherapy for lung cancer

Radiation-induced pulmonary toxicity remains a major concern in the standard of care radical (chemo)radiotherapy treatment for lung cancer. Approximately 15% of patients suffer from severe symptoms in the first 6  months after treatment, while a larger subgroup present mild symptoms [1]. To manage the toxicity risk in clinical routine, normal tissue complication probability (NTCP) models predicting severe adverse events are applied. These models are based on the correlation of radiation pneumonitis with th e mean lung dose (MLD) or the relative lung volume receiving 20 Gy (V20) [2,3].
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research