Probiotics for cow ’s milk protein allergy: a systematic review of randomized controlled trials

Conclusion: Limited low-quality evidence indicates that probiotic supplementation may be associated with earlier acquisition of tolerance to CMP in children with CMPA. Large well-designed trials are essential to confirm these findings.What is Known:•Cow ’s milk protein allergy (CMPA) is one of the commonest food allergies in children. CMPA is associated with significant socioeconomic burden.•Elimination diet and extensively hydrolyzed formula is the mainstay of the management of CMPA.What is New:•This first systematic review of randomized controlled trials shows that probiotics as an adjuvant can lead to earlier acquisition of tolerance to CMP in children at 36  months of age. However, the evidence is low quality and influenced by data from one large study.•Probiotic supplementation was not associated with earlier resolution of hematochezia.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research