Primary and Secondary Prevention of Cardiovascular Disease in Patients with Chronic Kidney Disease

AbstractPurpose of ReviewNon-dialysis-dependent chronic kidney disease (NDD-CKD) patients are at an increased risk of cardiovascular disease (CVD) –related deaths in comparison with the general population. This review summarizes recent guideline recommendations and studies on primary and secondary prevention of traditional cardiovascular (CV) risk factors in those with NDD-CKD.Recent FindingsThe use of antiplatelet agents for primary prevention in CKD is not supported by clinical trial evidence; however, they offer potential benefits when used for secondary prevention of CVD in the absence of an elevated bleeding risk. Lipid-lowering therapy reduces CV risk and is recommended for all NDD-CKD patients. In light of recent clinical trial findings, current clinical practice guidelines recommend a blood pressure (BP) goal
Source: Current Atherosclerosis Reports - Category: Cardiology Source Type: research

Related Links:

DiscussionWe estimated higher risks of ALL in the offspring of women with pregestational diabetes. These results are consistent with previous findings and compatible with a role of prenatal glycaemic environment in childhood cancer aetiology.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
ConclusionsA bleeding revision is associated with significantly reduced survival and substantially increased morbidity during LVAD support. Preoperative, intraoperative, and postoperative prophylactic strategies may help to prevent this life-threatening complication.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: Available online 20 July 2019Source: The Annals of Thoracic SurgeryAuthor(s): Yas Sanaiha, Behdad Kavianpour, Peter Downey, Raveendra Morchi, Richard J. Shemin, Peyman BenharashAbstractBackgroundIn the current era of value based healthcare delivery, an understanding of patient populations at greatest risk for mortality, complications, and readmissions after Thoracic Endovascular Aortic Repair (TEVAR) is warranted. Thus, the present study aimed to evaluate outcomes after TEVAR for patients with varying degrees of renal dysfunction.MethodsAll patients who underwent TEVAR from 2010-2015 in the NRD were ident...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
ConclusionsIn our experience, this approach is a reliable platform for a variety of MICS procedures and has resulted in low complication rates. The technique can be applied safely to both paediatric and adult population. Also, it is very cost effective as regular instruments and cannulas are used.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Arbutin protects HK-2 cells against high glucose-induced apoptosis and autophagy by up-regulating microRNA-27a. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):2940-2947 Authors: Lv L, Zhang J, Tian F, Li X, Li D, Yu X Abstract Arbutin (ARB) has been widely used in skin pigmentation disorders. Nevertheless, the involvements of ARB in diabetic nephropathy (DN) are still unknown. We investigated the functions of ARB in high glucose (HG)-induced cell apoptosis and autophagy in HK-2 cells. Cell viability was examined through CCK-8 in HK-2 cells after disposal with 45 mM glucose and ARB (10-50&th...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Publication date: Available online 20 July 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Tina Hörbelt, Birgit Knebel, Pia Fahlbusch, David Barbosa, Daniella Herzfeld de Wiza, Frederique Van de Velde, Yves Van Nieuwenhove, Bruno Lapauw, G. Hege Thoresen, Hadi Al-Hasani, Dirk Müller-Wieland, D. Margriet Ouwens, Jorg KotzkaAbstractSecreted frizzled-related protein (sFRP) 4 is an adipokine with increased expression in white adipose tissue from obese subjects with type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). Yet, it is unknown whether sFRP4 action contributes ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
Publication date: Available online 20 July 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Nikolay Solovyev, Frank Vanhaecke, Bernhard MichalkeAbstractDiabetes mellitus is a chronic metabolic disease caused by insulin deficiency (type I) or dysfunction (type II). Diabetes is a threatening public health concern. It is considered as one of the priority non-communicable diseases, due to its high and increasing incidence, the associated healthcare costs, and threatening medical complications. Two trace elements selenium (Se) and iodine (I) were intensively discussed in the context of diabetic pathology ...
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
This study and the proposed mechanism provide insights into the future studies of drying drops under different physical conditions. Further we explore the statistical characteristics of the single and interacting drops using the field emission scanning electron microscopy (FESEM) images. Next, we report fractal and image texture analyses along with object shape statistics of the drop FESEM images, under various experimental conditions. Several statistical hypothesis tests have been carried out to identify the most significant features.Graphical abstract
Source: Chemical Engineering Science - Category: Chemistry Source Type: research
This study reports a green, efficient, convenient and universal strategy for the preparation of antibacterial polyacrylate/Ag nanocomposite coatings via emulsion polymerization. In this work, a new type of polymerizable emulsifier, sodium mono dodecyl maleate (SMDM) was successfully synthesized, which also acted as an anionic ligand to achieve the uniform dispersion of Ag NPs in the polymer matrix by electrostatic interaction with Ag NPs. X-ray diffraction indicated that Ag NPs were successfully introduced into the coatings. Meanwhile, the results of transmission electron microscopy and scanning electron microscope demonst...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
CONCLUSION: Cranial MRI should be performed to identify the presence of brain abscesses in elderly patients with K. pneumoniae bloodstream infections but without clinically evident neurological signs or symptoms. Serial MRI studies are important to monitor the therapeutic course. PMID: 31321760 [PubMed - in process]
Source: Acta Neurologica Taiwanica - Category: Neurology Tags: Acta Neurol Taiwan Source Type: research
More News: Bleeding | Cardiology | Cardiovascular | Cholesterol | Chronic Kidney Disease | Clinical Trials | Diabetes | Diabetes Type 2 | Dialysis | Endocrinology | Heart | SGLT2 Inhibitors | Smokers | Sodium | Statin Therapy | Study | Urology & Nephrology | Weight Loss