Vps13b is required for acrosome biogenesis through functions in Golgi dynamic and membrane trafficking.

Vps13b is required for acrosome biogenesis through functions in Golgi dynamic and membrane trafficking. Cell Mol Life Sci. 2019 Jun 19;: Authors: Da Costa R, Bordessoules M, Guilleman M, Carmignac V, Lhussiez V, Courot H, Bataille A, Chlémaire A, Bruno C, Fauque P, Thauvin C, Faivre L, Duplomb L Abstract The sperm acrosome is a lysosome-related organelle that develops using membrane trafficking from the Golgi apparatus as well as the endolysosomal compartment. How vesicular trafficking is regulated in spermatids to form the acrosome remains to be elucidated. VPS13B, a RAB6-interactor, was recently shown involved in endomembrane trafficking. Here, we report the generation of the first Vps13b-knockout mouse model and show that male mutant mice are infertile due to oligoasthenoteratozoospermia. This phenotype was explained by a failure of Vps13b deficient spermatids to form an acrosome. In wild-type spermatids, immunostaining of Vps13b and Rab6 revealed that they transiently locate to the acrosomal inner membrane. Spermatids lacking Vps13b did not present with the Golgi structure that characterizes wild-type spermatids and showed abnormal targeting of PNA- and Rab6-positive Golgi-derived vesicles to Eea1- and Lamp2-positive structures. Altogether, our results uncover a function of Vps13b in the regulation of the vesicular transport between Golgi apparatus, acrosome, and endolysosome. PMID: 31218450 [PubMed - as supplied by publisher]
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Tags: Cell Mol Life Sci Source Type: research

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The objective was to evaluate the relationship between insulin resistance and serum homocysteine in subjects with polycystic ovarian syndrome (PCOS). Material and Methods: Cross sectional Case Control observational study done in Department of Obstetrics and Gynecology, KGMU Lucknow. Cases were 50 PCOS women as a study group and 40 women with infertility due to isolated male cause as a control group. Serum homocysteine levels compared in PCOS patients. Results: Mean homocysteine raised in cases (11.8 ± 5.5μmol/L) than control (7.8 ± 2.2 μmol/L), p
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
We report here a 20 year old phenotypically male who presented with gynaecomastia and found to have testis on right side and left inguinoscrotal swelling consisting of ovary, uterus and fallopian tubes. Evaluation revealed SRY negative 46 XX karyotype. He underwent surgical removal of ovary and mullerian structures. The highlight of case is development of testicular tissue in absence of SRY gene. PMID: 31315334 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
A tubo-ovarian abscess (TOA) is an emergent and potentially life-threatening illness. Rapid administration of antibiotics, interventional radiology abscess drainage, and/or gynecologic surgery are critical interventions. The goal is to prevent abscess rupture, which can lead to peritonitis, severe sepsis, recurrent hospitalizations, and, in rare circumstances, death [1]. Although mortality from TOA in the U.S. is uncommon, the result of an untreated TOA can have lasting damaging effects to pelvic organs and increase the risk of infertility, ectopic pregnancy, ovarian vein thrombosis, and chronic pelvic pain [2].
Source: Journal of Adolescent Health - Category: Child Development Authors: Tags: Editorial Source Type: research
This article presents recommendations of the Polish Psychiatric Association regarding approach to pregnancy loss and unsuccessful in vitro treatment of infertility. From the psychological perspective pregnancy loss and perinatal death are amongst the most stressful events in human life - carrying increased risk of developing affective, anxiety or post-traumatic stress disorders. Psychologists, physicians and the rest of the medical staff should provide integrated and individualized care which should be based on respect, empathy and expertise. The necessary phases of support for women experiencing pregnancy loss are: (1) ph...
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
Radioprotective effect of ethanolic extract of Alocasia indica on γ-irradiation-induced reproductive alterations in ovary and uterus. Int J Radiat Biol. 2019 Jul 17;:1-41 Authors: Prasad SK, Bose A, Bhattacharjee A, Banerjee O, Singh S, Mukherjee S, Pal S Abstract Evaluation of the modulatory effect of ethanolic extract of Alocasia indica tuber (EEAIT) against γ-irradiation induced ovarian and uterine toxicity. Extract preparation was done by 80% hydro-ethanol using Soxhlet apparatus. EEAITwas administered to female swiss albino mice (n = 5) daily (200 and 400 mg/kg bod...
Source: International Journal of Radiation Biology - Category: Radiology Tags: Int J Radiat Biol Source Type: research
Condition:   Infertility of Uterine Origin Intervention:   Procedure: Uterine Transplant from Deceased Donor Sponsor:   Brigham and Women's Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 19 July 2019Source: Journal of Minimally Invasive GynecologyAuthor(s): Aude Jayot, Sofiane Bendifallah, Carole Abo, Alexandra Arfi, Clémentine Owen, Emile DaraiABSTRACTLaparoscopic discoid colorectal resection is a surgical option for bowel endometriosis, one of the most severe forms of endometriosis. However, no study has clearly analysed the feasibility, or the complication and recurrence rates of the procedure in a homogeneous population with specific criteria for discoid resection. The aims were to evaluate the rate of conversion to segmental resection, the need for double disc...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
CONCLUSION: The results unveil distinct expression patterns of individual Slc2a glucose transporters during early embryo development. Taken together, they provide novel insights into the understanding and management of glucose metabolic infertility in assisted-reproductive technologies (ART). PMID: 31312354 [PubMed]
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
ALEXA CHUNG has recently revealed that she is battling with a condition that ‘sucks’ and could leave a woman infertile. What is it and who is at risk?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health News Source Type: news
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