Protein methylation functions as the posttranslational modification switch to regulate autophagy.

Protein methylation functions as the posttranslational modification switch to regulate autophagy.
Cell Mol Life Sci. 2019 Jun 19;:
Authors: Li R, Wei X, Jiang DS
Abstract
Studies over the past decades have elucidated the critical role of autophagy in human health and diseases. Although the processes of autophagy in the cytoplasm have been well studied, the posttranscriptional and epigenetic regulation mechanisms of autophagy are still poorly understood. Protein methylation, including histone methylation and non-histone protein methylation, is the most important type of posttranscriptional and epigenetic modification. Recent studies have shown that protein methylation is associated with effects on autophagosome formation, autophagy-related protein expression, and signaling pathway activation, but the details are still unclear. Thus, it is important to summarize the current status and discuss the future directions of research on protein methylation in the context of autophagy.
PMID: 31222372 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - June 18, 2019 Category: Cytology Authors: Li R, Wei X, Jiang DS Tags: Cell Mol Life Sci Source Type: research