Can Statins be Protagonists in Our Approach to Cancer Treatment?

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Source: American Journal of Clinical Oncology - Category: Cancer & Oncology Tags: Editorial Source Type: research

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Mojgan Rastegar Medulloblastoma is a common pediatric brain tumor and one of the main types of solid cancers in children below the age of 10. Recently, cholesterol-lowering “statin” drugs have been highlighted for their possible anti-cancer effects. Clinically, statins are reported to have promising potential for consideration as an adjuvant therapy in different types of cancers. However, the anti-cancer effects of statins in medulloblastoma brain tumor cells are not currently well-defined. Here, we investigated the cell death mechanisms by which simvastatin mediates its effects on different human...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
This review focuses on the role of oxidized sterols in three major gastrointestinal cancers (hepatocellular carcinoma, pancreatic and colon cancer) and how the circadian clock affects the carcinogenesis by regulating the lipid metabolism and beyond. While each field of research (cancer, oxysterols, and circadian clock) is well studied within their specialty, little is known about the intertwining mechanisms and how these influence the disease etiology in each cancer type. Oxysterols are involved in pathology of these cancers, but final conclusions about their protective or damaging effects are elusive, since the effect dep...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
The mevalonate pathway (also known as the cholesterol biosynthesis pathway) plays a crucial metabolic role in normal cell function as well as in the pathological environment. It leads to the synthesis of sterol and non-sterol isoprenoid biomolecules which subserve a variety of cellular functions. It is known to be deregulated in many disease processes. Statins and bisphosphonates are prominent inhibitors of the mevalonate pathway. They inhibit cell proliferation and activate apoptotic signalling and suppress tumour growth. Statins subdue metastatic spread of tumours by virtue of their ability to suppress invasion and angio...
Source: Current Cancer Therapy Reviews - Category: Cancer & Oncology Source Type: research
By WILLIAM H. BESTERMANN JR., MD New Scientific Breakthroughs Can Provide a Longer Healthier Life Twenty-one years of follow-up comparing usual care with a protocol-driven team-based intervention in diabetes proved that healthy life in humans can be prolonged by 8 years. These results were achieved at a lower per patient per year cost. Aging researchers have been confident that we will soon be able to prolong healthy life. This landmark study shows this ambitious goal can be achieved now with lifestyle intervention and a few highly effective proven medications. These medications interfere with the core molecular biol...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Medical Practice Patients aging chronic disease Denmark Diabetes William Bestermann Source Type: blogs
Conclusion: The use of statins does not affect PCa development/progression in patients with elevated PSA levels, nor the development of BCR after RP.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Communication Source Type: research
Carefully weigh benefits of hormone suppression against risks for men with prolonged life expectancy Related items fromOnMedica Fund specialist dementia training to improve care and save money New evidence on benzodiazepine link to Alzheimer ’s Statin use after stroke not linked to bleeds Some antipsychotics linked to raised mortality in dementia One in 10 children in phase I cancer trials respond to drugs
Source: OnMedica Latest News - Category: UK Health Source Type: news
Source: Gastroenterology - Category: Gastroenterology Authors: Source Type: research
Retrospective data show a 32% reduction in stroke and nonsignificant 15% reduction in cardiovascular and cerebrovascular events with postradiation statin therapy for thorax or head or neck cancer.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - Category: Neurology Tags: Cardiology News Source Type: news
Retrospective data show a 32% reduction in stroke and nonsignificant 15% reduction in cardiovascular and cerebrovascular events with postradiation statin therapy for thorax or head or neck cancer.Medscape Medical News
Source: Medscape Critical Care Headlines - Category: Intensive Care Tags: Cardiology News Source Type: news
Whether statin use has any impact on survival of esophageal cancer patients remains controversial. Therefore, we conducted a meta-analysis focusing on current topic for the first time. We systematically searched the following databases for relevant studies comparing survival between statin users and non-users among esophageal cancer patients up to March 16, 2019: Pubmed, Embase, and Web of Science. We extracted data of hazard ratio (HR) with 95%confidence interval (CI) of all-cause and cancer-specific mortality for analysis. We used the STATA 12.0 software to perform this meta-analysis. We finally included a total of 4 c...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Meta-Analysis of Observational Studies in Epidemiology Source Type: research
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