A bacterial remnant may explain arthritis in Lyme patients
New Yale research offers insight into why some Lyme disease patients continue to suffer from debilitating arthritis even after antibiotic treatment.
Source: Yale Science and Health News - Category: Universities & Medical Training Source Type: news
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Conditions: Lyme Disease; Lyme Neuroborreliosis; Lyme Arthritis; Unknown Origin Fever Intervention: Device: Scientific Consciousness Interface Operations (SCIO) Class II FDA approved medical device Sponsor: Kasey Phifer Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Borreliosis (Lyme disease) is a spirochetal disease caused by the species complex ofBorrelia burgdorferi transmitted byIxodes spp. ticks. Recorded to be the most common tick ‐borne disease in the world, the last two decades have seen an increase in disease incidence and distribution, exceeding 360 000 cases in Europe alone. If untreated, infection may cause skin symptoms, arthritis, and neurological or cardiac complications. Borrelia spirochetes have developed strate gies to evade the mammalian host immune system. These include the complement system, which is an important first‐line defense mechanism against...
Source: FEBS Letters - Category: Biochemistry Authors: Vinaya Dulipati,
Seppo Meri,
Jaana Panelius Tags: Review Article Source Type: research
In conclusion, These results reveal new possibilities for the treatment of Lyme arthritis.
PMID: 32829087 [PubMed - as supplied by publisher]
Source: International Immunopharmacology - Category: Allergy & Immunology Authors: Peng Y, Chen T, Luo L, Li L, Cao W, Xu X, Zhang Y, Yue P, Dai X, Ji Z, Jian M, Bai R, Ding Z, Wang F, Wen S, Zhou G, Kong J, Luo S, Liu A, Bao F Tags: Int Immunopharmacol Source Type: research
AbstractBorreliosis (Lyme disease) is a spirochetal disease caused by the species complex ofBorrelia burgdorferi transmitted byIxodes spp. ticks. Recorded to be the most common tick ‐borne disease in the world, the last two decades have seen an increase in disease incidence and distribution, exceeding 360 000 cases in Europe alone. If untreated, infection may cause skin symptoms, arthritis, neurological or cardiac complications. Borrelia spirochetes have developed strategies to evade the mammalian host immune system. These include the complement system, which is an important first‐line defence mechanism against invadin...
Source: FEBS Letters - Category: Biochemistry Authors: V Dulipati,
S Meri,
J Panelius Tags: REVIEW Source Type: research
Pathogen specific antibody responses need to be tightly regulated to generate protective but limit self-reactive immune responses. While loss of humoral tolerance has been associated with microbial infections, the pathways involved in balancing protective versus autoreactive antibody responses in humans are incompletely understood. Studies in classical mouse model systems have provided evidence that balancing of immune responses through inhibitory receptors is an important quality control checkpoint. Genetic differences between inbred mouse models and the outbred human population and allelic receptor variants not present i...
Source: eLife - Category: Biomedical Science Tags: Immunology and Inflammation Source Type: research
Title: What Happens if You Go Untreated for Lyme Disease?Category: Diseases and ConditionsCreated: 6/17/2020 12:00:00 AMLast Editorial Review: 6/29/2020 12:00:00 AM
Source: MedicineNet Arthritis General - Category: Rheumatology Source Type: news
Lyme borreliosis is the most prevalent tick-borne disease in the northern hemisphere.1 Over the last decades, marked increases in the incidence of Lyme borreliosis have been reported in several Western European countries and the United States (US), with substantial impact on public health.2 –6 Erythema migrans is the most common early skin manifestation of the disease, and responds well to antibiotic treatment.7 However, erythema migrans is often not observed preceding disseminated Lyme borreliosis manifestations such as neuroborreliosis, Lyme arthritis and Lyme carditis.
Source: Journal of Infection - Category: Infectious Diseases Authors: M.G. Harms, A. Hofhuis, H. Sprong, S.C. Bennema, J.A. Ferreira, M. Fonville, A. Docters van Leeuwen, W.J.J. Assendelft, H.C.P.M. Van Weert, W. Van Pelt, C.C. Van den Wijngaard Source Type: research
Title: What Are the Symptoms of Lyme Disease by Stages?Category: Diseases and ConditionsCreated: 6/17/2020 12:00:00 AMLast Editorial Review: 6/17/2020 12:00:00 AM
Source: MedicineNet Arthritis General - Category: Rheumatology Source Type: news
(Virginia Tech) With a $661,216 grant from the Steven&Alexandra Cohen Foundation, Brandon Jutras, an assistant professor of biochemistry in the Virginia Tech College of Agriculture and Life Sciences, will study Lyme arthritis, including the cellular component that contributes to it.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
(Washington State University) The next time a tick feeds on you, Washington State University researchers hope to make sure persistent arthritis caused by Lyme disease doesn't linger for a lifetime.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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