Diagnosis and management of childhood aplastic anaemia

Aplastic anaemia (AA) is a rare and heterogeneous disorder. AA results in pancytopenia and a hypocellular bone marrow in the absence of an abnormal infiltrate, major dysplasia or marrow fibrosis. In children, most cases are idiopathic and caused by T lymphocyte-mediated destruction of haemopoietic stem and progenitor cells (HSPC's). Inherited bone marrow failure syndromes (IBMFS) account for around 20% of cases and have to be excluded. This can be challenging but has specific implications for management.

Source: Paediatrics and Child Health - June 20, 2019 Category: Pediatrics Authors: Katherine Clesham, Neha Bhatnagar, Sujith Samarasinghe Tags: Symposium: haematology Source Type: research