Class-action lawsuit filed in Calgary over breast implants and cancer

Allergan Inc. is facing legal action after a type of breast implants it sold was linked by Health Canada to a higher risk of a rare form of non-Hodgkin's lymphoma.
Source: CBC | Health - Category: Consumer Health News Tags: News/Canada/Calgary Source Type: news

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Under pressure from the Food and Drug Administration, Allergan will stop selling textured implants. 33 deaths have been tied to this type of implant.
Source: NYT - Category: American Health Authors: Tags: Allergan Inc Cancer Breasts Implants Non-Hodgkin ' s Lymphoma Recalls and Bans of Products Food and Drug Administration your-feed-healthcare Source Type: news
Many other countries have already banned the products. But the U.S. agency said the risk was still low, despite repeated requests from women and doctors that the implants be removed from the market.
Source: NYT - Category: American Health Authors: Tags: Breasts Implants Recalls and Bans of Products Food and Drug Administration Plastic Surgery Non-Hodgkin ' s Lymphoma Allergan Inc your-feed-science your-feed-healthcare Source Type: news
Conclusion: This prospective multicenter study provides information on the current incidence and outcome of IFD in the real life setting. Practice variation between the centers may help to ultimately improve antifungal management in children at highest risk for IFDs. Introduction Available data on the incidence and outcome of invasive fungal diseases (IFD) in children treated for a hematological malignancy or undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are mostly based on single site, retrospective studies or on studies performed prior to the availability of newer compounds such as broad-sp...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Discussion In this section, we discuss the mechanisms responsible for lymphomagenesis in the various inborn errors of immunity and provide an overview of the treatment. Defects in Immune Responses That Predispose to Lymphomagenesis in PIDDs The complex immune mechanisms and their interplay that predisposes to neoplastic transformation of B or T cells and development of lymphomas in PIDD patients has not been fully elucidated. However, it is expected that the etiology in most cases is multifactorial and related to a dynamic regulation of immune response and environmental triggers (Figure 3). An underlying intrinsic susce...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusions: CAR T cell therapies have demonstrated the clinical benefits of harnessing our body's own defenses to combat tumor cells. Similar research is being conducted on lesser known modifications and gene-modified immune cells, which we highlight in this review. Introduction Chimeric antigen receptors and engineered T cell receptors (based on previously identified high affinity T cell receptors) function by redirecting T cells to a predefined tumor-specific (or tumor-associated) target. Most of these modifications use retroviral or lentiviral vectors to integrate the construct, and most of the receptors ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
The company ’ s product, in use worldwide, has been under scrutiny since women began developing a type of lymphoma.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Implants Breasts Medical Devices Plastic Surgery Non-Hodgkin's Lymphoma France Allergan Inc Cancer Recalls and Bans of Products Europe Source Type: news
Women with breast implants have an increased risk of a type of lymphoma that can usually be cured by surgery alone — but not always.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Implants Breasts Allergan Inc Breast Cancer Non-Hodgkin's Lymphoma Mentor Worldwide LLC Food and Drug Administration American Society for Aesthetic Plastic Surgery Source Type: news
oit Y Abstract Asparaginase is an essential component of combination chemotherapy for childhood acute lymphoblastic leukemia and non-Hodgkin's lymphoma. The value of asparaginase was further addressed in a group of non-very high risk patients by comparing a prolonged (long-asparaginase) versus standard (short-asparaginase) native E.coli asparaginase treatment through a randomized question as part of the phase III 58951 trial of the European Organisation for Research and Treatment of Cancer Children's Leukemia Group. The main endpoint was disease-free survival. Overall, 1,552 patients were randomly assigned to long...
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research
A rare cancer of the immune system, linked to implants, has had devastating effects on women, many of whom had reconstructive surgery after breast cancer.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Implants Allergan Inc Immune System Surgery and Surgeons Cancer Non-Hodgkin's Lymphoma Breasts Plastic Surgery Source Type: news
Conclusions: We found evidence of independent effects among the genetic and non-genetic factors with risk of CLL. Among these factors, the PRS had the largest effect size. Although we did not observe any statistical interactions, larger sample sizes are warranted to fully evaluate these effects on risk of CLL. We are currently increasing our sample size through collaboration with other research groups. Final results will be presented in the meeting.This abstract is also being presented as Poster A06.Citation Format: Geffen Kleinstern, Dennis Robinson, Tim G. Call, Mark Liebow, Silvia de Sanjosé, Yolanda Benavente, J...
Source: Cancer Epidemiology Biomarkers and Prevention - Category: Cancer & Oncology Authors: Tags: Improving Cancer Risk Prediction for Prevention and Early Detection: Oral Presentations - Proffered Abstracts Source Type: research
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