Rivaroxaban pharmacodynamics in healthy volunteers evaluated with thrombin generation and the active protein C system: modeling and assessing inter-individual variability.

CONCLUSIONS: This low-to-moderate rivaroxaban PD variability in healthy volunteers contrasts with the substantial PK variability, and deserves to be studied in different patient settings. This article is protected by copyright. All rights reserved.
PMID: 31215111 [PubMed - as supplied by publisher]

Source: Thrombosis and Haemostasis - June 18, 2019 Category: Hematology Authors: Siguret V, Abdoul J, Delavenne X, Curis E, Carlo A, Blanchard A, Salem JE, Gaussem P, Funck-Brentano C, Azizi M, Mismetti P, Loriot MA, Lecompte T, Gouin-Thibault I Tags: J Thromb Haemost Source Type: research