Phenolic constituents with neuroprotective activities from Hypericum wightianum

Publication date: September 2019Source: Phytochemistry, Volume 165Author(s): Ling Yang, Zi-Ming Wang, Yun Wang, Rong-Sheng Li, Fei Wang, Kou WangAbstractFive undescribed phenolic compounds, inclusing a depsidone derivative, hyperwightin A, a flavone derivative, hyperwightin B, and three benzophenone glycosides, hyperwightins C-E, along with four known ones were isolated from the 95% EtOH extract of the whole plants of Hypericum wightianum. Structures of the obtained compounds were elucidated by spectroscopic analyses. The protective effects of the isolates against corticosterone-induced PC12 cell injury were assessed. Hyperwightin E, petiolin G and hyperxanthone exhibited noticeable neuroprotection at 10 μM.Graphical abstract

Source: Phytochemistry - June 21, 2019 Category: Chemistry Source Type: research