Nor-guanacastepene pigments from the Chilean mushroom Cortinarius pyromyxa

Publication date: September 2019Source: Phytochemistry, Volume 165Author(s): Yen T.H. Lam, Götz Palfner, Celia Lima, Andrea Porzel, Wolfgang Brandt, Andrej Frolov, Haider Sultani, Katrin Franke, Christoph Wagner, Kurt Merzweiler, Ludger A. Wessjohann, Norbert ArnoldAbstractFor the first time, the pigment composition of basidiocarps from the Chilean mushroom Cortinarius pyromyxa was studied under various aspects like phylogeny, chemistry and antibiotic activity. A molecular biological study supports the monotypic position of C. pyromyxa in subgenus Myxacium, genus Cortinarius. Four undescribed diterpenoids, named pyromyxones A-D, were isolated from fruiting bodies of C. pyromyxa. Their chemical structures were elucidated based on comprehensive one- and two-dimensional NMR spectroscopic analysis, ESI-HRMS measurements, as well as X-ray crystallography. In addition, the absolute configurations of pyromyxones A-D were established with the aid of JH,H, NOESY spectra and quantum chemical CD calculation. The pyromyxones A-D possess the undescribed nor-guanacastane skeleton. Tested pyromyxones A, B, and D exhibit only weak activity against gram-positive Bacillus subtilis and gram-negative Aliivibrio fischeri as well as the phytopathogenic fungi Botrytis cinerea, Septoria tritici and Phytophthora infestans.Graphical abstract
Source: Phytochemistry - Category: Chemistry Source Type: research