Synthesis, cytotoxicity and antineoplastic activities of novel acridine-based platinum(II) organometallic complexes

Publication date: Available online 21 June 2019Source: Journal of Organometallic ChemistryAuthor(s): Nur Amajeida Ismail, Abbas Abdulameer Salman, Mohd Sukeri Mohd Yusof, Siti Kamilah Che Soh, Khomaizon Abdul Kadir Pahirulzaman, Hapipah Mohd Ali, Rozie SaripAbstractTwo new platinum(II) complexes incorporating acridine ligands with aniline moieties were successfully synthesised and characterised. The acridine-based ligands were synthesised by means of Ullmann's condensation. The reaction of cis-[PtCl2(DMSO)2] with the aforementioned ligand in a specified mol ratio gives 9-phenylaminoacridine cis-dichloro(dimethylsulfoxide)-platinum(II), 2a, and bis-[N-(3,5-dimethoxyphenyl) acridin-9-amine)]chloro platinum(II), 2b. Apparently, both complexes were slightly planar and in discrete asymmetrical units. Cytotoxicity and antineoplastic activity evaluations were conducted using WRL-68, MCF-7, HT-29, and HL60 cell lines. The novel complexes exhibited potent activity towards the cell lines. Concurrently, the MTT cytotoxicity assay revealed that all complexes significantly inhibited the proliferation of MCF-7 and HL60 cells.Graphical abstract

Source: Journal of Organometallic Chemistry - June 21, 2019 Category: Chemistry Source Type: research