Dermal group 2 innate lymphoid cells in atopic dermatitis and allergy.

Dermal group 2 innate lymphoid cells in atopic dermatitis and allergy.
Curr Opin Immunol. 2014 Dec;31C:108-114
Authors: Roediger B, Kyle R, Le Gros G, Weninger W
Abstract
Type 2 immune responses in the skin cause a variety of pathologies, including urticaria and atopic dermatitis. Traditionally, CD4(+) helper T cells have been implicated in the pathogenesis of these conditions. However, recently a new player, the group 2 innate lymphoid (ILC2) cell, has emerged as an important contributor to skin allergies. In this review, we summarize our current knowledge of the role ILC2 cells play in the physiology and pathology of mouse and human skin.
PMID: 25459002 [PubMed - as supplied by publisher]

Source: Current Opinion in Immunology - December 1, 2014 Category: Allergy & Immunology Authors: Roediger B, Kyle R, Le Gros G, Weninger W Tags: Curr Opin Immunol Source Type: research