Distinct CD44 Splice Variants Differentially Affect Collateral Artery Growth.

Conclusion: Total CD44 and CD44v3 mRNA are upregulated during arteriogenesis. The absence of the variably spliced exon region impairs arteriogenesis. Presence of exon v3 of CD44 results in improved arteriogenesis. Expression of CD44s and CD44v3 provides a synergistic effect on arteriogenesis. As this combined expression still resulted in hampered arteriogenesis, a specific role of exon v2 in arteriogenesis appears likely.
PMID: 23391418 [PubMed - in process]

Source: Current Vascular Pharmacology - January 1, 2013 Category: Drugs & Pharmacology Authors: Bot PT, Grundmann S, van Royen N, Joosten SP, Schirmer SH, de Kleijn DP, Pals ST, Pasterkamp G, Piek JJ, Hoefer IE Tags: Curr Vasc Pharmacol Source Type: research