CD26 Inhibition Enhances Perfusion Recovery in ApoE-/-Mice.

Conclusions: CD26 inhibition enhanced perfusion recovery following arterial occlusion via attenuated SDF-1 alpha inactivation and increased monocyte activation. There was no observable aggravation of atherosclerosis and CD26 inhibition could therefore offer a novel approach for therapeutic arteriogenesis in patients.
PMID: 23391419 [PubMed - in process]

Source: Current Vascular Pharmacology - January 1, 2013 Category: Drugs & Pharmacology Authors: Haverslag RT, de Groot D, Grundmann S, Meder B, Goumans MJ, Pasterkamp G, Hoefer IE, de Kleijn DP Tags: Curr Vasc Pharmacol Source Type: research