Angiogenetic potential of ad2/hif-1α/vp16 after regional application in a preclinical pig model of chronic ischemia.

Conclusion: Retroinfusion of Ad2/Hif-1α/VP16, combining a master pro-angiogenic protein with regional myocardial application, may offer an efficient approach to cardiac gene therapy of chronic ischemic cardiomyopathy.
PMID: 23391420 [PubMed - in process]

Source: Current Vascular Pharmacology - January 1, 2013 Category: Drugs & Pharmacology Authors: Hinkel R, Lebherz C, Fydanaki M, Wuchrer A, El-Aouni C, Thormann M, Thein E, Kupatt C, Boekstegers P Tags: Curr Vasc Pharmacol Source Type: research