Optimized (pre) Analytic Conditions and Workflow for ddPCR Analysis of cfDNA from Patients Suspected of Lung Carcinoma

For patients suspected of lung carcinoma, the analysis of circulating tumor DNA, obtained by liquid biopsy, has the potential to support cancer diagnosis and guide targeted therapy. To ensure sensitive and reproducible detection of circulating tumor DNA in daily routine practice, a standardized (pre) analytical workflow is required. Plasma was obtained from patients and healthy volunteers. Using the Qiagen Circulating Nucleic Acid kit, six different procedures for the isolation of cell-free DNA (cfDNA) were compared.
Source: Journal of Molecular Diagnostics - Category: Pathology Authors: Tags: Regular Article Source Type: research

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To investigate the long term oncological follow up results and the relevant clinicopathologic prognostic factors for early stage (St IB1) cervical carcinoma patients who were surgically treated with Robot Assisted Radical Hysterectomy (RARH) or Open Radical Hysterectomy (ORH) from 2005 to 2012 at The Norwegian Radium Hospital.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Plenary 3: Oncology (3:05 PM – 4:05 PM) 3:25 PM Source Type: research
Ovarian cancer arising from benign endometriotic has been widely reported. cystic adenomyoma is a rare form of adenomyosis. And clear cell carcinoma arising from cystic adenomyosis is even more unusual. Here we report a case of clear cell carcinoma arising from cystic adenomyosis treated with laparoscopic surgery.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Virtual Poster Session 1: Laparoscopy (10:40 AM — 10:50 AM) 10:40 AM: STATION S Source Type: research
This video will exemplify the techniques necessary to safely complete a difficult dissection and debulking procedure in the obturator fossa in a patient with high-grade serous fallopian tube carcinoma.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Open Communications 2: Oncology (11:00 AM — 11:30 AM) 11:21 AM Source Type: research
Publication date: Available online 13 October 2019Source: Seminars in Cancer BiologyAuthor(s): Vikram Shaw, Suyash Srivastava, Sanjay K. SrivastavaAbstractThe recent development of high throughput compound screening has allowed drug repurposing to emerge as an effective avenue for discovering novel treatments for cancer. FDA-approved antipsychotic drugs fluspirilene, penfluridol, and pimozide are clinically used for the treatment of psychotic disorders, primarily schizophrenia. These compounds, belong to diphenylbutylpiperidine class of antipsychotic drugs, are the potent inhibitors of dopamine D2 receptor and calcium chan...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 12 October 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Laura Tatiana Pelegrina, Myriam LaconiAbstractOvarian carcinoma is one of the most common cause of death by gynecologic cancer. Several epidemiological and in vitro studies have shown controversial data about progesterone effects in ovarian cancer. Progesterone can be converted in its active metabolite, allopregnanolone, its effects in ovarian cancer are still unknown. Previously, we demonstrated that allopregnanolone modifies ovarian morphophysiology, being able to alter critical process of tumor d...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
There is no uniformity or consensus on the effective management of the N zero nodal basin in cSCC.
Source: ENTtoday - TRIO Best Practices - Category: ENT & OMF Authors: Tags: Head and Neck Practice Focus TRIO Best Practices cuteneous squamous cell carcinoma head and neck cancer neck dissection parotidectomy Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
We report an unprecedented case of squamous cell carcinoma (SCC) in the floor of mouth of a 23-year-old woman with XP. The patient was referred to the oncologist and, two months after surgical resection, underwent a single chemotherapy and radiotherapy session. However, she died 73 hours after undergoing her first chemotherapy session. Considering the unexpected outcome of this case, we also investigated possible exacerbated adverse effects of antineoplastic treatments (especially cisplatin-based chemotherapy) in XP patients, and discussed the main characteristics of the disease, especially cases with oral manifestations d...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Publication date: Available online 12 October 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): C.M. Bowe, B. Gurney, S. Whitaker, C. NewlandsAbstractThis is the third of three articles that give an overview of the current evidence for management of the neck and parotid in patients with cutaneous cancers of the head and neck. In this paper we discuss Merkel cell carcinoma (MCC) and review the latest evidence for management of the regional nodes.
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
AbstractHow to differentiate thyroid cancer nodules from a large number of benign nodules is always a challenging subject for clinicians. This paper proposes a novel Sal-deel network model to achieve the classification and diagnosis of thyroid cancer, which can simulate visual attention mechanism. The Sal-deep network introduces saliency map as an additional information on the deep residual network, which selectively enhances the feature extracted from different regions according to the mask map. Sal-deep network can work effectively for the benchmark networks with different data sets and different structures, and it is a ...
Source: Journal of Medical Systems - Category: Information Technology Source Type: research
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