Effect of MUC1 length polymorphisms on the NLRP3 inflammasome response of human macrophages.

This study evaluated the effect of MUC1 VNTR polymorphisms on activity of the NLRP3 inflammasome in human macrophages, finding that long MUC1 alleles correlated with increased IL-1β production following NLRP3 inflammasome activation. This indicates that the length of MUC1 can influence IL-1β production, thus providing the first evidence of an immune-modulatory role of MUC1 VNTR polymorphisms in human macrophages.
PMID: 31213370 [PubMed - as supplied by publisher]

Source: Human Immunology - June 14, 2019 Category: Allergy & Immunology Authors: Dhar P, Sarkar S, Ng GZ, Kalitsis P, Saeed MA, McGuckin MA, Ellis JA, Sutton P Tags: Hum Immunol Source Type: research