Failure patterns after adjuvant chemoradiotherapy following endoscopic resection for superficial esophageal squamous cell carcinoma

ConclusionsLymph node recurrence frequently involved the elective nodal irradiation field, with recurrent nerve lymph nodes being common metastasis sites. The high incidence of nodal recurrence for T1b tumors with lymphovascular invasion highlights a need for new strategies for treating this subset of superficial esophageal squamous cell carcinomas.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research

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Accurate nodal staging is crucial for esophageal cancer. A prospective study was performed to assess the value of [18F] fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) for diagnosing cervical lymph node metastasis (LNM) of esophageal squamous cell carcinoma.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
This study evaluated the utility of pretreatment maximal esophageal wall thickness on CT scans to predict treatment outcomes after CRT in patients with locally advanced ESCC.MethodsEighty-one patients with T3 locally advanced ESCC, whom were treated completely with CRT with and without surgery, and had available CT scans before and after CRT at a university hospital between 2005 and 2015, were retrospectively reviewed.ResultTwenty patients (24.7%) had esophagectomy after neoadjuvant CRT and sixty-one patients (75.3%) had definitive CRT. The maximal esophageal wall thicknesses were measured retrospectively and correlated wi...
Source: Journal of Gastrointestinal Cancer - Category: Cancer & Oncology Source Type: research
Conclusions: Alleviated dysphagia might be a useful factor to predict the response to second-cycle NAC for first-cycle SD/PD patients. PMID: 31737296 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Computed tomography (CT) is commonly used in all stages of oesophageal squamous cell carcinoma (SCC) management. Compared to basic CT features, CT radiomic features can objectively obtain more information abou...
Source: Cancer Imaging - Category: Radiology Authors: Tags: Research article Source Type: research
This study assessed the risk factors of fistula based on clinical information on patients with chemoradiotherapy for T4-EC.MethodsWe retrospectively reviewed the clinical data of 59 T4-EC patients who had squamous cell carcinoma without any fistula before receiving definitive or palliative chemoradiotherapy.ResultsA fistula was observed in 18 patients (31%) throughout their clinical course. The overall survival in the fistula group was significantly shorter than that in the non-fistula group (259 vs. 346  days;p = 0.0341). The axial tumor size on computed tomography (CT) was confirmed as an independent r...
Source: Esophagus - Category: Gastroenterology Source Type: research
Conclusions: Preoperative sarcopenia is an independent risk factor for pulmonary infection after minimally invasive oesophagectomy (MIE). Evaluation of preoperative sarcopenia will thus help to prevent postoperative complications. PMID: 31372290 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
CONCLUSIONS: We conclude that high levels of intratumoral F. nucleatum have a prognostic significance for predicting poor RFS in ESCC patients. More importantly, our data indicates that higher F. nucleatum burden correlates with poor response to neoadjuvant chemotherapy, suggesting the possibility that an antibiotic intervention against this bacterium may significantly improve therapeutic response in ESCC patients. PMID: 31358543 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
Publication date: Available online 28 June 2019Source: International Journal of Surgery Case ReportsAuthor(s): Adel Elkbuli, Brianna Dowd, Mark McKenney, Dessy BonevaAbstractIntroductionThe occurrence of Neuroendocrine Carcinoma (NEC) of the colon is
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
We sought to evaluate the diagnostic performance of fluorine-18-fluorodeoxyglucose positron-emission tomography/computed tomography (18F-FDG PET/CT) in the detection of metastatic lymph nodes by combined interpre...
Source: Cancer Imaging - Category: Radiology Authors: Tags: Research article Source Type: research
220Objectives: To evaluate the diagnostic performance of 18F-FDG PET/CT in detecting individual lymph node metastasis using Hounsfield units of lymph nodes on non-contrast CT image component and 18F-FDG uptake in patients with esophageal squamous cell carcinoma. Methods: 203 patients with esophageal squamous cell carcinoma underwent 18F-FDG PET/CT before esophagectomy and lymph node dissection. Maximum standardized uptake value (SUVmax), mean Hounsfield unit (HU), and short axis diameters (size) were evaluated on non-contrast CT and PET images of PET/CT scan. The images were analyzed by three methods. In Method 1, nodal st...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: GI & amp;acirc; amp;euro; ' Colorectal, Liver, Esophageal Source Type: research
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