Researchers Identify Genes Linked to Increased Ovarian Cancer Risk

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Source: Oncology Times - Category: Cancer & Oncology Tags: Opinion Source Type: research

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Contributor : Shengtao ZhouSeries Type : Expression profiling by high throughput sequencing ; Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensOvarian cancer is a heterogeneous disease that constitutes great menace to female health and poses tremendous clinical challenge. Based on unsupervised classification of whole-genome gene expression profiles, four molecular subtypes of ovarian cancer were recently identified. However, currently it is still unelucidated on the immune infiltration pattern of different molecular subtypes of ovarian cancer. we used a computational approach (CIBERSORT) to bulk...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
Condition:   Advanced Ovarian Cancer Intervention:   Drug: SC10914 Sponsor:   Jiangxi Qingfeng Pharmaceutical Co. Ltd. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Ovarian Neoplasms;   Fallopian Tube Neoplasms;   Endocrine Gland Neoplasms;   Neoplasms by Site;   Neoplasms;   Genital Neoplasms, Female;   Urogenital Neoplasms;   Neoplasms, Glandular and Epithelial;   Neoplasms by Histologic Type;   Carcinoma, Ovarian Epithelial;   Ovarian Diseases;   Adnexal Diseases;   Genital Diseases, Female;   Endocrine System Diseases;   Gonadal Disorders;   Carcinoma;   Bevaci...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Advanced Ovarian Cancer Intervention:   Drug: SC10914 Sponsor:   Jiangxi Qingfeng Pharmaceutical Co. Ltd. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Ovarian Neoplasms;   Fallopian Tube Neoplasms;   Endocrine Gland Neoplasms;   Neoplasms by Site;   Neoplasms;   Genital Neoplasms, Female;   Urogenital Neoplasms;   Neoplasms, Glandular and Epithelial;   Neoplasms by Histologic Type;   Carcinoma, Ovarian Epithelial;   Ovarian Diseases;   Adnexal Diseases;   Genital Diseases, Female;   Endocrine System Diseases;   Gonadal Disorders;   Carcinoma;   Bevaci...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Long non‑coding RNA MCM3AP‑AS1 drives ovarian cancer progression via the microRNA‑143‑3p/TAK1 axis. Oncol Rep. 2020 Jul 17;: Authors: Wen J, Han S, Cui M, Wang Y Abstract The long non‑coding RNA (lncRNA) MCM3AP antisense 1 (MCM3AP‑AS1) has previously been shown to be a key regulator of multiple types of cancer; however whether it is important in the context of ovarian cancer (OC) is uncertain. The present study determined that MCM3AP‑AS1 expression in samples from patients with OC was significantly increased, and was associated with tumor stage, presence of lymph node metastases and poore...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Long non‑coding RNA NEAT1 modifies cell proliferation, colony formation, apoptosis, migration and invasion via the miR‑4500/BZW1 axis in ovarian cancer. Mol Med Rep. 2020 Aug 04;: Authors: Xu H, Sun X, Huang Y, Si Q, Li M Abstract Ovarian cancer (OC) is a frequently occurring malignant tumor in women. Increasing evidence has indicated that long non‑coding RNA (lncRNA) nuclear paraspeckle assembly transcript 1 (NEAT1) participates in OC pathogenesis. Thus, the aim of the present study was to explore the function of NEAT1 during OC progression. The expression levels of NEAT1, microRNA (miR)‑...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Long non‑coding RNA NEAT1 promotes ovarian cancer cell invasion and migration by interacting with miR‑1321 and regulating tight junction protein 3 expression. Mol Med Rep. 2020 Aug 11;: Authors: Luo M, Zhang L, Yang H, Luo K, Qing C Abstract Previous studies have reported that long non‑coding RNAs (lncRNAs) have a significant role in the metastasis of tumors, including ovarian cancer (OC). The aim of the present study was to demonstrate the function and working mechanism of lncRNA nuclear enriched abundant transcript 1 (NEAT1) in OC. The expressions of NEAT1 in OC were measured by reverse transcr...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Ovarian cancer is the eighth leading cause of death from cancer in women worldwide, with an estimated 185,000 deaths in 2018, representing 4% of all cancer deaths in women [1]. The relapsing nature of the disease has a profound impact on patients and their quality of life (QoL).
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Authors: Tags: Anti-tumour Treatment Source Type: research
AbstractOvarian seromucinous carcinoma (SMC) is an uncommon neoplasia and is composed predominantly of serous and endocervical-type mucinous epithelium. Due to its low frequency and difficult diagnosis, the natural history, characteristic imaging findings, and pathological features of SMC have not been adequately described in the literature thus far. We herein report three cases of ovarian SMC along with magnetic resonance imaging (MRI) findings. The diagnosis of SMC was made after staging laparotomy in all cases, and systemic chemotherapy was performed in two cases. No recurrence was observed in any of the cases. The MRI ...
Source: International Cancer Conference Journal - Category: Cancer & Oncology Source Type: research
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