Delineating the Plausible Molecular Vaccine Candidates and Drug Targets of Multidrug-Resistant Acinetobacter baumannii
Nosocomial infections have become alarming with the increase of multidrug resistant bacterial strains of Acinetobacter baumannii. Being the causative agent in approximately 80% of the cases, these pathogenic gram-negative species could be deadly for hospitalized patients, especially in intensive care units utilizing ventilators, urinary catheters and nasogastric tubes. Primarily infecting an immuno-compromised system, they are resistant to most antibiotics and are the root cause of various types of opportunistic infections including but not limited to septicemia, endocarditis, meningitis, pneumonia, skin and wound sepsis and even urinary tract infections. Conventional experimental methods including typing, computational methods encompassing comparative genomics and combined methods of reverse vaccinology and proteomics had been proposed to differentiate and develop vaccines and/or drugs for several outbreak strains. However, identifying proteins suitable enough to be posed as drug targets and/or molecular vaccines against the multidrug resistant pathogenic bacterial strains has probably remained an open issue to address. In these cases of novel protein identification, either the targets are uncharacterized or have been unable to confer the most coveted protection either in the form of molecular vaccine candidates or as drug targets. Here, we report a strategic approach with the 3766 proteins from the whole genome of A. baumannii ATCC19606 (AB) to rationally identify plausible...
Authors: Brignardello-Petersen R PMID: 31606117 [PubMed - as supplied by publisher]
According to a new publication by the Council for Agricultural Science and Technology (CAST), the genetic diversity of livestock and poultry is declining, leaving one-third of the world’s protein supply at risk to extreme weather and disease outbreaks. CAST warns that “up to 25 percent of global livestock breeds are either at risk of being lost, or have already been lost.” The report discusses the risks associated with reduced access to genetic traits and recommends actions to protect remaining breeds that build on current conservation practices such as cryopreservation and germplasm repositories. &ldqu...
[Monitor] Several health centres in Apac District at the weekend remained non-functional as health workers underwent orientation on how to administer rubella and measles vaccine on children.
ConclusionsThe overall VTE rate after CABG has been low. However, the condition has been associated with worse 30-day postoperative outcomes and complications. The independent predictors of VTE development included a history of bleeding disorders, congestive heart failure in the 30 days before surgery, and operative time of ≥310 minutes. Understanding these risk factors should aid physicians in the decisions regarding prophylaxis and treatment.
[Vanguard] Health authorities in the Democratic Republic of Congo will introduce a Johnson&Johnson Ebola vaccine in November in the country's eastern provinces, to counter the current outbreak, they said.
Did the introduction of pneumococcal conjugate vaccines help decrease the incidence of pneumococcal meningitis?Emerging Infectious Diseases
By KIP SULLIVAN, JD The Medicare Payment Advisory Commission (MedPAC) and other proponents of the Hospital Readmissions Reduction Program (HRRP) justified their support for the HRRP with the claim that research had already demonstrated how hospitals could reduce readmissions for all Medicare fee-for-service patients, not just for groups of carefully selected patients. In this three-part series, I am reviewing the evidence for that claim. We saw in Part I and Part II that the research MedPAC cited in its 2007 report to Congress (the report Congress relied on in authorizing the HRRP) contained no studies supporting tha...
This brief primer reviews the pathophysiology of herpes zoster, and summarizes the results of the clinical trials of Shingrex, the newly approved recombinant vaccine for HZ prevention.Skin Therapy Letter
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