Which Weight Loss Drug for this Complex Patient?

She is 35 y/o with a history of migraine, bipolar disorder, and hypertension. Years of structured diets and nutrition consult have failed. Which agent would you consider?
Source: ConsultantLive - Category: Internal Medicine Authors: Tags: Gastrointestinal Disorders Source Type: news

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We hypothesized that the store-operated calcium entry (SOCE) channel, Orai1, participates in the activation of Th17 cells and influences renal injury. In rats, following renal ischemia/reperfusion (I/R), there was a rapid and sustained influx of Orai1+ CD4 T cells and IL-17 expression was restricted to Orai1+ cells. When kidney CD4+ cells of post–acute kidney injury (post-AKI) rats were stimulated with angiotensin II and elevated Na+ (10–7 M/170 mM) in vitro, there was an enhanced response in intracellular Ca2+ and IL-17 expression, which was blocked by SOCE inhibitors 2APB, YM58483/BTP2, or AnCoA4. In vivo, YM...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
RESUMO Objetivo: Avaliar poss íveis associações do risco nutricional com os desfechos clínicos desfavoráveis em pacientes críticos internados na unidade de terapia intensiva. Métodos: Estudo de coorte, prospectivo, realizado em 200 pacientes em unidade de terapia intensiva de hospital universitário. O risco nutricional foi avaliado pelos escores NRS-2002 e NUTRIC. Pacientes com escore ≥ 5 foram considerados de alto risco nutricional. Os dados e desfechos cl ínicos foram obtidos de registros clínicos dos pacientes. Utilizou-se análise de regress...
Source: Revista Brasileira de Terapia Intensiva - Category: Intensive Care Source Type: research
Conclusion: Septic patients with a past history of heart failure received 1L less IV fluids in the first 24 hours with no difference in mortality.
Source: Revista Brasileira de Terapia Intensiva - Category: Intensive Care Source Type: research
Bipolar disorder affects men and women in equal numbers, and the symptoms are essentially identical. But some key differences do exist—differences that might be due to biological factors, and social ones, too. For starters, research has consistently shown that women have higher rates of bipolar II disorder, “which typically presents as a chronic depressive disorder with periods of hypomania,” according to Candida Fink, MD, a board-certified child, adolescent and adult psychiatrist with a private practice in Westchester, N.Y. There’s a misconception that bipolar II disorder is less severe than bipola...
Source: Psych Central - Category: Psychiatry Authors: Tags: Bipolar Disorders Gender General Men's Issues Women's Issues Bipolar Disorder bipolar disorder and pregnancy bipolar I Bipolar Ii Gender Differences men and bipolar disorder menopause and bipolar disorder menstruation and bipolar Source Type: news
We present a case of MAOI-induced hypertensive crisis leading to significant troponin release after soft cheese intake. A 51-year-old lady presented with left-sided chest pain, palpitations and headache in the context of significant hypertension after eating soft cheese. She had a similar episode 2 month prior to this presentation, which resulted in a diagnosis of non-ST elevation myocardial infarction after a troponin of 2768 ng/L (Ref 
Source: Cardiovascular Toxicology - Category: Cardiology Authors: Tags: Cardiovasc Toxicol Source Type: research
We describe the effects of LDX (50mg and 70mg) on the Sheehan Disability Scale (SDS; exploratory endpoint) from both studies. Design: The SDS was assessed at baseline, Week 6, and Week 12/early termination. Analyses included mixed-effects models for repeated measures for the examination of SDS total and domain score changes and a generalized estimating equation model to assess dichotomized remission status (remission [total score ?6] versus nonremission [total score>6]). Results: Least squares (95% confidence interval [CI]) mean treatment differences for SDS total score change from baseline at Week 12 were -2.80 (-3.98,...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Drug Development Original Research binge eating disorder disability functionality lisdexamfetamine dimesylate Sheehan Disability Scale Source Type: research
The objective of this systematic review and meta-analysis was to examine the association between maternal chronic medical conditions (CMC) and perinatal mental illness. Medline, EMBASE, CINAHL, and PsycINFO were searched to September, 2017. Data were extracted and quality was assessed using standardized instruments. We generated unadjusted and adjusted pooled odds ratios (aPOR) and 95% confidence intervals (CI) using DerSimonian and Laird random effects models. The review included 16 papers representing 12 studies and 1,626,260 women. CMC overall was associated with perinatal mental illness overall (aPOR = 1.43, ...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research
Jennifer shared these comments about her husband’s early Wheat Belly transformation: “My husband found your site a while back while doing research into symptoms he’s been experiencing for years. After following your advice with food, the doctor visits have stopped and I have a normal husband back. “Prior to meeting him, he has always had issues with his weight and gut. He would exercise to the point of passing out and it just wouldn’t go anywhere. When I met him 5 years ago, he was jogging every night and exercising. He just couldn’t get the flabby stomach to go away and, every time the ...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Success Stories abdominal distress diabetes gluten grains headache IBS Inflammation obesity overweight Source Type: blogs
Authors: Sivananthan M, Mohiuddin S Abstract Valproate is a medication used in the treatment of seizures, bipolar disorder, migraines, and behavioral problems. Here we present a case of an 8-year-old boy who presented with hypertensive urgency after initiation of valproate. Primary treatment of his hypertension was ineffective. Blood pressure stabilization was achieved following discontinuation of valproate. Clinicians should be aware of the risk of developing hypertensive urgency with administration of valproate. PMID: 27403366 [PubMed]
Source: Case Reports in Psychiatry - Category: Psychiatry Tags: Case Rep Psychiatry Source Type: research
Director chair, film slate and load horn. Here’s a proposal for you: If, by following the Wheat Belly lifestyle, a long list of conditions are reduced or reversed at no risk, almost no cost, reversing even chronic and potentially fatal conditions . . . does that mean that the notion of self-directed health might be on the horizon, i.e., putting control over health back in our own hands? I think it does. No, we will never implant our own defibrillators or take out our own gallbladders. But so many chronic health conditions afflicting modern humans recede that I believe that it is entirely reasonable to start talking a...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle arthritis autoimmune diabetes eating disorder gluten grains Inflammation joint Weight Loss Source Type: blogs
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