Diagnostic accuracy of a velcro sound detector (VECTOR) for interstitial lung disease in rheumatoid arthritis patients: the InSPIRAtE validation study (INterStitial pneumonia in rheumatoid ArThritis with an electronic device)

Interstitial lung disease (ILD) is a severe systemic manifestation of rheumatoid arthritis (RA). High-resolution computed tomography (HRCT) represents the gold standard for the diagnosis of ILD, but its routin...
Source: BMC Pulmonary Medicine - Category: Respiratory Medicine Authors: Tags: Research article Source Type: research

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In this report, the clinical relevance of plasma Wnt5a protein was evaluated in 40 RA-ILD patients and 41 non-ILD RA cohorts. The results showed an elevated Wnt5a protein in plasmas of RA-ILD patients compared with non-ILD RA patients (p 
Source: Immunobiology - Category: Allergy & Immunology Authors: Tags: Immunobiology Source Type: research
Publication date: Available online 8 March 2019Source: Respiratory InvestigationAuthor(s): Tomoo KishabaAbstractIdiopathic Pulmonary Fibrosis (IPF) is a most common progressive interstitial lung disease (ILD) of unknown etiology, although majority of patients are elderly male smokers. The main pathogenesis is aberrant recovery of epithelial injury and collagen deposition. Fibrotic nonspecific interstitial pneumonia, connective tissue disease (CTD) especially rheumatoid arthritis (RA) associated ILD, and chronic hypersensitivity pneumonia(CHP) are important differential diagnosis. Main symptoms are non-productive cough and ...
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
New research has linked the risk of developing interstitial lung disease in rheumatoid arthritis patients with the promoter variant in MUC5B, which may also contribute to the development of idiopathic pulmonary fibrosis and an unsual interstitial pneumonia seen by high-resolution CT scan...
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Rheumatoid Arthritis ILD Interstitial Lung Disease MUC5B Rheumatoid Arthritis (RA) Source Type: research
Conclusions: The New staging system use CT images variables to predict mortality in patients with RA-ILD.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: ILD/DPLD of known origin Source Type: research
This study included 88 RA patients. ILD was diagnosed by high-resolution computed tomography (HRCT) and assessed by a severity score. Disease activity was assessed by clinical disease activity index (CDAI) and functional status by the modified health assessment questionnaire (MHAQ). Serum ACPA titer was assayed by ELISA.ResultsThe mean age of the patients was 50.15 ± 9 years, disease duration was 10.2 ± 6.2 years and they were 75 females and 13 males. ACPA was positive in 84 (95.5%). The frequency of ILD among RA patients was 71.6%. ILD patterns were: usual interstitial pneumonia (UIP) 6...
Source: The Egyptian Rheumatologist - Category: Rheumatology Source Type: research
This study impacts the RA and ILD fields by helping to identify a therapeutic treatment that may improve both diseases. As this model replicates the characteristics of RA-ILD, the results may be translatable to the human disease. PMID: 29543042 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - Category: Cytology Authors: Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research
Conclusion ILD frequency has increased among RA patients due to improved detection by HRCT. High titer of ACPA was associated with extent and patterns of severity of ILD in RA patients. When high ACPA titer is associated with low CDAI score, physician could suspect lung involvement.
Source: The Egyptian Rheumatologist - Category: Rheumatology Source Type: research
Conclusions: Pneumonia, bronchiectasis, and interstitial lung disease were the most common abnormalities seen in RA patients. The presence of comorbidity, male gender, and ExRA was significantly associated with lung involvement.
Source: Annals of Thoracic Medicine - Category: Respiratory Medicine Authors: Source Type: research
Interstitial lung disease is a common extra-articular manifestation of rheumatoid arthritis (RA-ILD) and is associated with significant morbidity and mortality. However, limited data exist regarding predictors of mortality. We sought to examine the prognostic value of the high-resolution computed tomography (HRCT) patterns in patients with RA-ILD.
Source: Respiratory Medicine - Category: Respiratory Medicine Authors: Source Type: research
Purpose of review: To provide an overview of recently published articles covering interstitial lung disease associated with rheumatoid arthritis (RA-ILD). Recent findings: Over the past year, many studies replicated previous findings in more diverse and occasionally larger populations internationally. Specifically, the association among cigarette smoking, high rheumatoid factor titer, elevated anticitrullinated protein antibody (ACPA) levels, and RA-ILD was strengthened. Clinical characteristics, autoantibodies, and biomarkers to aid in RA-ILD development, progression, and mortality prediction were explored. Finally, dire...
Source: Current Opinion in Rheumatology - Category: Rheumatology Tags: RHEUMATOID ARTHRITIS: Edited by Jon T. Giles Source Type: research
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