Blastic transformation of mantle cell lymphoma with B-lymphoblastic features

We present a case of mantle cell lymphoma with the typical phenotype, which transformed to a blastic morphology with loss of expression of CD20, CD5 and BCL2, and gain of CD10 and TdT. In cases presenting with blastic morphology, the use of CD10 and TdT in addition to the usual mantle cell lymphoma markers is essential since cases of mantle cell lymphoma with B-lymphoblastic features may require innovative treatment.

Source: Human Pathology: Case Reports - June 20, 2019 Category: Pathology Source Type: research