SILK studies — capturing the turnover of proteins linked to neurodegenerative diseases

Nature Reviews Neurology, Published online: 20 June 2019; doi:10.1038/s41582-019-0222-0Paterson and colleagues describe how stable isotope labelling kinetics (SILK) can be used to determine protein production and clearance rates. They highlight the promise of SILK studies for elucidating the role of pathogenic proteins in neurodegenerative diseases, including Alzheimer disease.

Source: Nature Reviews Neurology - June 19, 2019 Category: Neurology Authors: Ross W. Paterson Audrey Gabelle Brendan P. Lucey Nicolas R. Barth élemy Claire A. Leckey Christophe Hirtz Sylvain Lehmann Chihiro Sato Bruce W. Patterson Tim West Kevin Yarasheski Jonathan D. Rohrer Norelle C. Wildburger Jonathan M. Schott Celeste M. Kar Source Type: research