A Comprehensive Review of Local Pharmacologic Therapy for Pyoderma Gangrenosum.

A Comprehensive Review of Local Pharmacologic Therapy for Pyoderma Gangrenosum. Wounds. 2019 Jun;31(6):151-157 Authors: Baltazar D, Haag C, Gupta AS, Marzano AM, Ortega Loayza AG Abstract Pyoderma gangrenosum (PG) is a rare, ulcerative inflammatory skin disease that most commonly occurs in patients with inflammatory bowel disease, rheumatologic diseases, or hematologic diseases. Successful treatment of PG often requires immunosuppression and appropriate wound care. Systemic corticosteroids and cyclosporine are the first-line treatments for PG. However, chronic use of these systemic agents places patients at risk for developing significant side effects, including hyperglycemia, osteoporosis, hypertension, and weight gain. Furthermore, when treating small or superficial PG ulcers, the use of local agents as monotherapies or adjuvant treatments can be ideal to control inflammation and promote healing without placing the patient at risk for many severe side effects that can be seen with long-term use of systemic agents. This literature review assesses all available local therapies in order to summarize the use and reported efficaciousness of the broad range of local treatments available for PG. PMID: 31215868 [PubMed - in process]
Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research

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AbstractAplastic anemia (AA) has been reported to be associated with inflammatory bowel disease (IBD), but mostly with ulcerative colitis (UC). Little is known about the associations between AA and Crohn ’s disease (CD). We aim to determine the portraits of patients with AA-CD. Among a total of 657 patients with CD registered in Xijing Hospital of Digestive Diseases IBD center from January 2008 to October 2018, the patients diagnosed with concurrent AA were reviewed. Clinical presentation, medical history, endoscopic features, response to treatment, and prognosis in this set of patients were collected. Six male patie...
Source: Annals of Hematology - Category: Hematology Source Type: research
ConclusionHM might have some beneficial effects including improving insomnia, blood pressure, and mental health, for hypertensive elderly with insomnia. Since the methodological quality of the included studies and QoE were not high, well-designed RCTs are urgent to confirm these results.
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
HIGH blood pressure is a common condition that can lead to serious and even life-threatening health complications if left untreated. But one of the best ways to avoid these complications and keep blood pressure under control is by making healthy food swaps. So what ’s the best food to eat for breakfast?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Discussion Bardet-Biedl syndrome (BBS) is a rare disorder. It is usually considered an autosomal recessive disorder but there is significant intra-familial variability. There are multiple genes (~20 currently) involved and it is believed that the phenotypic variability is due to “…differences in the total mutational load across different BBS associated genes….” It is a ciliopathy where mutation changes in proteins in the cilias causes problems in the cilia’s functioning particularly signaling. Cilia are important in signaling to maintain tissue and cellular homeostasis. Obviously screening o...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
This study aimed to explore how lncRNA Tug1 affected the pulmonary vascular remodeling in HPH. A mouse model of HPH and a pulmonary artery smooth muscle cell (PASMC) model of HPH (HPH-PASMCs) were established, where the expression of lncRNA Tug1 was determined. Then, the interaction among lncRNA Tug1, miR-374c, and Foxc1 was assessed. Finally, in order to determine the effects of lncRNA Tug1 on PASMC activities and pulmonary vascular remodeling after HPH, the expression of lncRNA Tug1 was silenced in HPH-PASMCs and HPH mice, with the proliferation, apoptosis, and migration of PASMCs as well as blood pressure in mice measur...
Source: Life Sciences - Category: Biology Source Type: research
We pay special attention to restoration of magnesium in the Wheat Belly lifestyle. This is because magnesium deficiency is universal, affecting virtually everyone, is severe, and has substantial implications for health. But why? Why has everyone become so depleted in magnesium in the modern world? There are five major reasons: Water filtration—We filter our water out of necessity, since modern waterways are contaminated by sewage runoff, pesticide/herbicides, algal overgrowth, etc. So, rather than drinking from a nearby stream or river that runs freely over rocks and minerals rich in magnesium, we drink water filter...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Magnesium grain-free phytates undoctored wheat belly Source Type: blogs
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Authors: Nicolini A, Barbagelata E, Tagliabue E, Colombo D, Monacelli F, Braido F Abstract Chronic obstructive pulmonary disease (COPD) is generally considered to be prevalent in males. However, smoking is rising in women in developing and developed countries, while exposure to biomass fuel for domestic purposes is a recognized risk factor among females. Females developing more severe COPD patterns due to tobacco exposure than men maybe due to a genetic predisposition, a greater dose-dependent effect of smoke related to smaller airways caliber and an increased oxidative stress with augmented TGF-beta1 signaling. Ge...
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
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Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - Category: Biomedical Science Authors: Tags: Original research article Source Type: research
Glucocorticoids (such as prednisolone) are anti-inflammatory drugs commonly used to treat both acute and chronic inflammatory diseases, including gout, pulmonary infection, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and psoriasis [1,2]. Intake of glucocorticoids is high, especially in the US, where the prevalence of oral glucocorticoids in the general population is around 1.2% [3]. Glucocorticoid treatment is associated with multiple adverse effects, including systemic hypertension, impaired glucose metabolism and overt diabetes, dyslipidemia, osteoporosis, muscle and skin atrophy and increased su...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - Category: Biomedical Science Authors: Source Type: research
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