Research Techniques Made Simple: Using Genetic Variants for Randomization

Observational epidemiological studies have identified associations between a number of modifiable exposures and outcomes, including in dermatology, such as between smoking and psoriasis. However, it is challenging to determine if such relationships are causal because of the potential of confounding and reverse causation. Mendelian randomization (MR) is a statistical method that can be used to investigate the causal relationships between an exposure and outcome by using a genetic instrument that proxies the exposure.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Research Techniques Made Simple Source Type: research