Sex-dependent effects of early unstable post-natal environment on response to positive and negative stimuli in adult mice

Publication date: Available online 20 June 2019Source: NeuroscienceAuthor(s): Matteo Di Segni, Diego Andolina, Sebastian Luca D’Addario, Lucy Babicola, Donald Ielpo, Alessandra Luchetti, Tiziana Pascucci, Luisa Lo Iacono, Francesca R. D'Amato, Rossella VenturaAbstractAlterations in early environmental conditions that interfere with the creation of a stable mother-pup bond have been suggested to be a risk factor for the development of stress-related psychopathologies later in life. The long-lasting effects of early experiences are mediated by changes in various cerebral circuits, such as the corticolimbic system, which processes aversive and rewarding stimuli. However, it is evident that the early environment is not sufficient per se to induce psychiatric disorders; interindividual (eg, sex-based) differences in the response to environmental challenges exist. To examine the sex-related effects that are induced by an early experience on later events in adulthood, we determine the enduring effects of repeated cross-fostering (RCF) in female and male C57BL/6J mice. To this end, we assessed the behavioral phenotype of RCF and control (male and female) mice in the saccharine preference test and cocaine-induced conditioned place preference to evaluate the response to natural and pharmacological stimuli and in the elevated plus maze test and forced swimming test to measure their anxiety- and depression-like behavior. We also evaluated FST-induced c-Fos immunoreactivity in vario...
Source: Neuroscience - Category: Neuroscience Source Type: research

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CONCLUSIONS: Disorders of mother infant bonding are seen in healthy postpartum mothers. The frequency of mild disorders of bonding appears to be similar across countries and this condition warrants further attention. PMID: 31326768 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
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Source: Journal of Maternal-Fetal and Neonatal Medicine - Category: Perinatology & Neonatology Authors: Source Type: research
Maternal prenatal depressive or anxiety symptoms are associated with adverse maternal and infant health outcomes. With prevalence rates of maternal prenatal depression and anxiety ranging between 10 and 20%, a...
Source: Trials - Category: General Medicine Authors: Tags: Study protocol Source Type: research
Conditions:   Pregnancy Related;   Stress, Psychological;   Anxiety;   Perinatal Depression Interventions:   Behavioral: SMART Pregnancy;   Behavioral: Treatment as usual Sponsors:   Stony Brook University;   Massachusetts General Hospital;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractPrenatal maternal depression is associated with developmental disorders in offspring. However, the specific effects of the intensity of prenatal depressive symptoms on infant behavior remain poorly explored. The aim of this work is to explore the links between early neonatal behavior and maternal prenatal depressive symptoms, independently from maternal pre- and postnatal anxiety and early postnatal maternal depressive symptoms. Five hundred and ninety-eight women and their newborns from the MATQUID cohort were prospectively evaluated during the 8th month of pregnancy (T1) and at day 3 postpartum (T2). We analyzed ...
Source: European Child and Adolescent Psychiatry - Category: Psychiatry Source Type: research
Conditions:   Depression, Postpartum;   Anxiety Intervention:   Behavioral: Therapist-assisted ICBT Sponsor:   University of Regina Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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