Differential Expression of Transforming Growth Factor-β1 Is Associated With Fetal Regeneration After Myocardial Infarction

ConclusionsTGF-β1 is increased in adult infarcts compared with regenerative, fetal infarcts after MI. Although treatment of fetal cardiac fibroblasts with TGF-β1 conveys an adult phenotype, inhibition of TGF-β1 conveys a fetal phenotype to adult cardiac fibroblasts. Decreasing TGF-β1 after MI may facilitate myocardial regeneration by “fetalizing” the otherwise fibrotic, adult response to MI.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research