Evoked Compound Action Potentials Reveal Spinal Cord Dorsal Column Neuroanatomy

DiscussionECAP dispersion increases with propagation distance due to the contribution of slow ‐conducting small‐diameter fibers as the signal propagates away from the source. An analysis of the discontinuities in ECAP dispersion changes with propagation revealed that these are due to the termination of smaller‐diameter, slower‐conducting fibers at corresponding segmental levels. The implications regarding SCS lead placement, toward the goal of maximizing clinical benefit while minimizing side‐effects, are discussed.Conflict of InterestJohn Parker is the founder and CEO of Saluda Medical and holds stock options. Milan Obradovic, Nastaran Hesam Shariati, Dean M. Karantonis, Peter Single, James Laird ‐Wah, Robert Gorman and Mark Bickerstaff are employees of Saluda Medical with stock options. At the time the data was collected for the study, Prof. Cousins was a paid consultant for Saluda Medical. John Parker, Milan Obradovic, Dean Karantonis, James Laird‐Wah, Robert Gorman and Peter Single ar e co‐inventors in one or more patents related to the topics discussed in this work.
Source: Neuromodulation: Technology at the Neural Interface - Category: Biotechnology Authors: Tags: Basic Research Source Type: research