RCT: Endovascular therapy after intravenous t-PA versus t-PA alone for stroke

Source: NEJM Area: News A study, published early online in the New England Journal of Medicine, assessed the effectiveness of using endovascular therapy after the administration of intravenous tissue plasminogen activator (t-PA) by comparing this approach with the use of intravenous t-PA alone.   Patients who had received intravenous t-PA within 3 hours were randomly assigned in a 2:1 ratio to receive additional endovascular therapy or no additional therapy. The primary outcome measure was a modified Rankin scale score of 2 or less (indicating functional independence) at 90 days (scores range from 0 to 6, with higher scores indicating greater disability).   The study was halted early after 656 participants had undergone randomisation (434 patients to endovascular therapy and 222 to intravenous t-PA alone) because of futility. The authors reported the following results: . The proportion of participants with a modified Rankin score of 2 or less at 90 days did not differ ...
Source: NeLM - News - Category: Drugs & Pharmacology Source Type: news