Tumor Grade and Matrix Metalloproteinase 2 Expression in Stromal Fibroblasts Help to Stratify the High-Risk Group of Patients With Early Breast Cancer Identified on the Basis of St Gallen Recommendations.

CONCLUSION: To the best of our knowledge, we have shown for the first time that MMP-2(-) in stromal fibroblasts might indicate poor survivors in the group of patients with grade 3 tumors and that the cumulative effect of both above-mentioned parameters might be helpful in selecting the high-risk individuals from the group of patients with luminal B subtype/HER2(+)/triple negative phenotype identified according to St Gallen recommendations. PMID: 23375518 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/PubMed/23375518?dopt=Abstract

Source: Clinical Breast Cancer - January 30, 2013 Category: Cancer & Oncology Authors: Niemiec J, Adamczyk A, Małecki K, Ambicka A, Ryś J Tags: Clin Breast Cancer Source Type: research