Common variants of genes encoding TLR4 and TLR4 pathway members TIRAP and IRAK1 are effective on MCP1, IL6, IL1 β, and TNFα levels in type 2 diabetes and insulin resistance

AbstractObjective and designType 2 diabetes is a pandemic disease characterized by hyperglycemia, ineffective insulin use, and insulin resistance and affecting 1 in 11 people worldwide. Inflammation-related insulin resistance is thought to play an important role in the etiology of the disease. TLR4 is the central receptor of the natural immune system and has an important role as a trigger of the inflammatory response. The IRAK1 and TIRAP are members of the TLR4 pathway and involved in the TLR4-mediated inflammatory response. Genetic variants in the TLR4 gene or in the IRAK1 and TIRAP genes may have an important role in the development of insulin resistance and type 2 diabetes by disrupting the inflammatory response. In this direction, we aimed to investigate the relationship among TLR4 and IRAK1, TIRAP gene variants, and type 2 diabetes and insulin resistance, and investigate how these variants affect inflammatory factors (TNF- α, IL-6, MCP-1, and IL-1β).Subjects and methodsIn our study, a total of seven variations on the genes of TLR4 (rs4986790, rs4986791), IRAK1 (rs1059703, rs3027898, rs7061789), and TIRAP (rs8177374, rs8177400) were genotyped by the MassARRAY® Iplex GOLD SNP genotyping in 100 type 2 diabetic patients and 100 non-diabetic individual. The TLR4 rs4986790 and rs4986791 variation was confirmed by PCR –RFLP method also. The serum IL1-β, IL6, MCP-1, and TNF-α levels were measured using enzyme-linked immunosorbent assay kits.Result...
Source: Inflammation Research - Category: Research Source Type: research

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Type 2 diabetes (T2D), commonly accompanied by cardiovascular disease (CVD) risk factors (e.g. hypertension, high cholesterol, and smoking), has posed a major challenge to society, patients, and families, as an emerging global pandemic [1]. A recent study using the National Health and Nutrition Examination Survey data reported that diabetes and prediabetes (including undiagnosed cases) affected almost half of the US adult population. However the results also exhibited a sex bias with the potential underestimation for the prevalence of diabetes and prediabetes in women due to physiological differences between men and women [2,3].
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
The pandemic of cardiovascular disease (CVD) and type 2 diabetes (T2D) requires the identification of new predictor biomarkers. Biomarkers potentially modifiable with lifestyle changes deserve a special intere...
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Tags: Original investigation Source Type: research
(Natural News) Researchers from India and the U.S. conducted a pilot study to determine if the polyphenolic extract from unopened clove buds can influence glucose metabolism. The results of their study were published in the journal BMC Complementary and Alternative Medicine. Type 2 diabetes is considered a global pandemic and is a huge contributor to the...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
FRIDAY, Oct. 11, 2019 -- The risk for hospitalization with pandemic influenza is higher for patients with type 2 diabetes than for those without type 2 diabetes, according to a study published online Oct. 6 in the Journal of Internal Medicine. Paz...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Obesity has reached the pandemic level. It has dramatically increased over recent decades and is now one of the most important public health problems facing both urban and rural areas.1 Among youths, the worldwide prevalence of overweight and obesity has risen by 47.1% since 1980.2 Pediatric obesity is associated with comorbidities affecting the cardiovascular (CV), pulmonary, endocrine, gastrointestinal, and musculoskeletal systems,3 and it seems to be the predominant cause of conditions such as hypertension, type 2 diabetes mellitus, dyslipidemia, insulin resistance, inflammation, and steatohepatitis.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Editorial Source Type: research
AbstractChildhood obesity has reached pandemic proportions, and youth-onset type 2 diabetes is following suit. This review summarises the literature on the influence of developmental overnutrition, resulting from maternal diabetes, obesity, maternal dietary intake during pregnancy, excess gestational weight gain, and infant feeding practices, on the aetiology of obesity and type 2 diabetes risk during childhood and adolescence. Key goals of this review are: (1) to summarise evidence to date on consequences of developmental overnutrition; (2) describe shared and distinct biological pathways that may link developmental overn...
Source: Diabetologia - Category: Endocrinology Source Type: research
There is a global pandemic of type 2 diabetes mellitus (T2DM), especially in Asia. Singapore has a prevalence of T2DM at 10.5%, which is higher than the world average of 8.8%. Multiple studies have shown that ...
Source: Trials - Category: General Medicine Authors: Tags: Study protocol Source Type: research
In this study, we aimed to investigate the impact of intensive multidisciplinary diabetes mellitus care with patient empowerment versus routine clinical care on the rate of progression of micro and macrovascular complications and peripheral atherosclerotic burden, as measured by changes in femoral intima-media thickness (IMT) in patients with persistently elevated HbA1c and nephropathy.MethodsThe study is a single-center randomized controlled trial (RCT) with two study arms - intensive diabetes mellitus care versus routine clinical care. Patients in the intensive arm will receive care from a multidisciplinary team consisti...
Source: Trials - Category: Research Source Type: clinical trials
 Study of Impact of Glycemic Status (HbA1c) on Platelet Activity measured by Mean Platelet Volume &Vascular Complications in Diabetics. J Assoc Physicians India. 2019 Apr;67(4):26-29 Authors: Saluja M, Swami YK, Meena SR Abstract Introduction: Diabetes mellitus is a global pandemic. The increased platelet activity may play a role in the development of vascular complications of this metabolic disorder. The mean platelet volume (MPV) is an indicator of the average size and activity of platelets. Larger platelets are younger and exhibit more activity. Aims and Objectives: To determine the MPV...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
AbstractAlzheimer ’s disease (AD) is an irreversible, progressive disease that slowly destroys cognitive function, such as thinking, remembering, and reasoning, to a level that one cannot carry out a daily living. As people live longer, the risk of developing AD has increased to 1 in 10 among people who are older t han 65 and to almost 1 in 2 among those who are older than 85 according to a 2019 Alzheimer’s Association report. As a most common cause of dementia, AD accounts for 60–80% of all dementia cases. AD is characterized by amyloid plaques and neurofibrillary tangles, composed of extracellular aggre...
Source: Neurotherapeutics - Category: Neurology Source Type: research
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